Technology Process of C15H15NO2
There total 4 articles about C15H15NO2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-bromo-4-isopropoxybenzene;
With
n-butyllithium;
In
diethyl ether; hexane;
at -78 ℃;
for 1h;
Inert atmosphere;
Cooling with acetone-dry ice;
N-methoxy-N-methylpyridine-3-carboxamide;
In
tetrahydrofuran; diethyl ether; hexane;
at -78 - 20 ℃;
for 4.5h;
Inert atmosphere;
Cooling with acetone-dry ice;
DOI:10.1021/jm2015809
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere; Cooling with ice
2.1: triethylamine / dichloromethane / 0 - 20 °C
3.1: n-butyllithium / diethyl ether; hexane / 1 h / -78 °C / Inert atmosphere; Cooling with acetone-dry ice
3.2: 4.5 h / -78 - 20 °C / Inert atmosphere; Cooling with acetone-dry ice
With
n-butyllithium; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide;
In
diethyl ether; hexane; dichloromethane;
DOI:10.1021/jm2015809
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 0 - 20 °C
2.1: n-butyllithium / diethyl ether; hexane / 1 h / -78 °C / Inert atmosphere; Cooling with acetone-dry ice
2.2: 4.5 h / -78 - 20 °C / Inert atmosphere; Cooling with acetone-dry ice
With
n-butyllithium; triethylamine;
In
diethyl ether; hexane; dichloromethane;
DOI:10.1021/jm2015809
