1-<4-methoxy-2-(methoxymethoxy)-3-(trimethylsilyl)phenyl>-3-<4-(benzyloxy)phenyl>-1-propanol

Base Information

• Chemical Name: 1-<4-methoxy-2-(methoxymethoxy)-3-(trimethylsilyl)phenyl>-3-<4-(benzyloxy)phenyl>-1-propanol
• CAS No.: 89321-22-2
• Molecular Formula: C₂₈H₃₆O₅Si
• Molecular Weight: 480.676
• Mol file: 89321-22-2.mol

Synonyms:1-<4-methoxy-2-(methoxymethoxy)-3-(trimethylsilyl)phenyl>-3-<4-(benzyloxy)phenyl>-1-propanol

Chemical Property of 1-<4-methoxy-2-(methoxymethoxy)-3-(trimethylsilyl)phenyl>-3-<4-(benzyloxy)phenyl>-1-propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<4-methoxy-2-(methoxymethoxy)-3-(trimethylsilyl)phenyl>-3-<4-(benzyloxy)phenyl>-1-propanol

There total 5 articles about 1-<4-methoxy-2-(methoxymethoxy)-3-(trimethylsilyl)phenyl>-3-<4-(benzyloxy)phenyl>-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methoxy-3-(methoxymethoxy)benzene (57234-28-3) → 1-<4-methoxy-2-(methoxymethoxy)-3-(trimethylsilyl)phenyl>-3-<4-(benzyloxy)phenyl>-1-propanol (89321-22-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) tert-butyllithium / 1.) hexane, pentane, THF, 2h, 0 degC 2.) room temp., 20h

2: 1.) tert-butyllithium / 1.) hexane, pentane, 0 deg C, 4.5h 2.) THF, 2h, 0-10 deg C

With tert.-butyl lithium;

DOI:10.1021/jo00183a036

Reference yield:

3-[4-(benzyloxy)phenyl]propan-1-ol (61440-45-7) → 1-<4-methoxy-2-(methoxymethoxy)-3-(trimethylsilyl)phenyl>-3-<4-(benzyloxy)phenyl>-1-propanol (89321-22-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / pyridinium dichromate / CH₂Cl₂ / 22 h / Ambient temperature

2: 1.) tert-butyllithium / 1.) hexane, pentane, 0 deg C, 4.5h 2.) THF, 2h, 0-10 deg C

With dipyridinium dichromate; tert.-butyl lithium; In dichloromethane;

DOI:10.1021/jo00183a036

Reference yield:

3-(4-hydroxyphenyl)propan-1-ol (10210-17-0) → 1-<4-methoxy-2-(methoxymethoxy)-3-(trimethylsilyl)phenyl>-3-<4-(benzyloxy)phenyl>-1-propanol (89321-22-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) sodium hydride / 1.) DMF, 50 deg C 2.) 50 deg C

2: 79 percent / pyridinium dichromate / CH₂Cl₂ / 22 h / Ambient temperature

3: 1.) tert-butyllithium / 1.) hexane, pentane, 0 deg C, 4.5h 2.) THF, 2h, 0-10 deg C

With dipyridinium dichromate; tert.-butyl lithium; sodium hydride; In dichloromethane;

DOI:10.1021/jo00183a036

upstream raw materials:

3-(4-(benzyloxy)phenyl)propanal

3-methoxy-2-(trimethylsilyl)-1-(methoxymethoxy)benzene

3-[4-(benzyloxy)phenyl]propan-1-ol

3-(4-hydroxyphenyl)propan-1-ol

Downstream raw materials:

1-<4-methoxy-2-(methoxymethoxy)-3-(trimethylsilyl)phenyl>-3-<4-(benzyloxy)phenyl>-1-propyl acetate

Broussonin A

4-<3-<4-methoxy-2-(methoxymethoxy)phenyl>propyl>-phenol

1-<4-methoxy-2-(methoxymethoxy)phenyl>-3-<4-(benzyloxy)phenyl>-1-propyl acetate