N-[2-(4-cyanophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-4-fluoro-N-methylbenzamide

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Chemical Name:N-[2-(4-cyanophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-4-fluoro-N-methylbenzamide
CAS No.:139982-01-7
Molecular Formula:C₂₁H₁₅F₇N₄O
Molecular Weight:472.365
Hs Code.:

Synonyms:N-[2-(4-cyanophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-4-fluoro-N-methylbenzamide

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Chemical Property of N-[2-(4-cyanophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-4-fluoro-N-methylbenzamide

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Technology Process of N-[2-(4-cyanophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-4-fluoro-N-methylbenzamide

There total 4 articles about N-[2-(4-cyanophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-4-fluoro-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 151-50-8
potassium cyanide

: 139981-81-0
4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-N-methyl-benzamide

: 139982-02-8
4-Cyano-N-[2-(4-cyano-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-N-methyl-benzamide

: 139982-01-7
N-[2-(4-cyanophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-4-fluoro-N-methylbenzamide

Guidance literature:: With potassium carbonate; potassium iodide; In dimethyl sulfoxide; at 130 - 140 ℃;
DOI:10.1016/S0968-0896(97)00058-8

Reference yield:

: 81659-38-3
α,α-bis(trifluoromethyl)-4,5-bis(4-fluorophenyl)-1-methyl-1H-imidazole-2-methanamine

: 139982-01-7
N-[2-(4-cyanophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-4-fluoro-N-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / m-chloroperbenzoic acid / CH₂Cl₂ / Heating

2: 96 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

3: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, overnight

4: 28 percent / KI, K₂CO₃ / dimethylsulfoxide / 130 - 140 °C

With lithium aluminium tetrahydride; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; potassium iodide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0968-0896(97)00058-8

Reference yield:

: 4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-3,5-dihydro-imidazol-(4Z)-ylidene]-benzamide

: 139982-01-7
N-[2-(4-cyanophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluoromethyl)-1H-imidazol-5-yl]-4-fluoro-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, overnight

3: 28 percent / KI, K₂CO₃ / dimethylsulfoxide / 130 - 140 °C

With lithium aluminium tetrahydride; sodium hydride; potassium carbonate; potassium iodide; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/S0968-0896(97)00058-8