2-chloro-5-[4-(4-chloro-3-fluorophenyl)-3-methyl-1,1-dioxido-2,3-dihydro-1,2,5-thiadiazol-3-yl]pyridine

Base Information

Chemical Name:2-chloro-5-[4-(4-chloro-3-fluorophenyl)-3-methyl-1,1-dioxido-2,3-dihydro-1,2,5-thiadiazol-3-yl]pyridine
CAS No.:1199793-12-8
Molecular Formula:C₁₄H₁₀Cl₂FN₃O₂S
Molecular Weight:374.223
Hs Code.:

Synonyms:2-chloro-5-[4-(4-chloro-3-fluorophenyl)-3-methyl-1,1-dioxido-2,3-dihydro-1,2,5-thiadiazol-3-yl]pyridine

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Chemical Property of 2-chloro-5-[4-(4-chloro-3-fluorophenyl)-3-methyl-1,1-dioxido-2,3-dihydro-1,2,5-thiadiazol-3-yl]pyridine

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Technology Process of 2-chloro-5-[4-(4-chloro-3-fluorophenyl)-3-methyl-1,1-dioxido-2,3-dihydro-1,2,5-thiadiazol-3-yl]pyridine

There total 10 articles about 2-chloro-5-[4-(4-chloro-3-fluorophenyl)-3-methyl-1,1-dioxido-2,3-dihydro-1,2,5-thiadiazol-3-yl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1199793-11-7
2-amino-1-(4-chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propan-1-one

: 1199793-12-8
2-chloro-5-[4-(4-chloro-3-fluorophenyl)-3-methyl-1,1-dioxido-2,3-dihydro-1,2,5-thiadiazol-3-yl]pyridine

Guidance literature:: With SULFAMIDE; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; at 95 ℃; for 42h; Molecular sieve;

Reference yield: 80.0%

: 1199793-11-7
2-amino-1-(4-chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propan-1-one

: 7803-58-9
SULFAMIDE

: 1199793-12-8
2-chloro-5-[4-(4-chloro-3-fluorophenyl)-3-methyl-1,1-dioxido-2,3-dihydro-1,2,5-thiadiazol-3-yl]pyridine

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; at 95 ℃; for 18h; Molecular sieves 4?;

Reference yield:

: 55676-22-7
3-acetyl-6-chloropyridine

: 1199793-12-8
2-chloro-5-[4-(4-chloro-3-fluorophenyl)-3-methyl-1,1-dioxido-2,3-dihydro-1,2,5-thiadiazol-3-yl]pyridine

Guidance literature:: Multi-step reaction with 8 steps

1.1: ammonium hydroxide; ammonium chloride / methanol / 72 h / 20 °C

1.2: 2 h / Reflux; Cooling with ice

2.1: triethylamine / tetrahydrofuran / 36 h / Reflux

2.2: Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice

3.2: Cooling with ice

4.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 2 h / 20 °C

5.1: tetrahydrofuran / 1 h / Cooling with ice

6.1: acetic anhydride; dimethyl sulfoxide / 18 h / 20 °C / Cooling with ice

7.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C / Cooling with ice

8.1: SULFAMIDE; 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 42 h / 95 °C / Molecular sieve

With hydrogenchloride; ammonium hydroxide; lithium aluminium tetrahydride; sulfur trioxide pyridine complex; acetic anhydride; SULFAMIDE; ammonium chloride; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dimethyl sulfoxide;