2-amino-1-(4-chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propan-1-one

Base Information

Chemical Name:2-amino-1-(4-chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propan-1-one
CAS No.:1199793-11-7
Molecular Formula:C₁₄H₁₁Cl₂FN₂O
Molecular Weight:313.159
Hs Code.:

Synonyms:2-amino-1-(4-chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propan-1-one

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Chemical Property of 2-amino-1-(4-chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propan-1-one

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Technology Process of 2-amino-1-(4-chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propan-1-one

There total 8 articles about 2-amino-1-(4-chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1199793-10-6
tert-butyl [2-(4-chloro-3-fluorophenyl)-1-(6-chloropyridin-3-yl)-1-methyl-2-oxoethyl]carbamate

: 1199793-11-7
2-amino-1-(4-chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propan-1-one

Guidance literature:: tert-butyl [2-(4-chloro-3-fluorophenyl)-1-(6-chloropyridin-3-yl)-1-methyl-2-oxoethyl]carbamate; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h; Cooling with ice;

With sodium hydroxide; In water;

Reference yield:

: 1199793-07-1
ethyl 2-[(tert-butoxycarbonyl)amino]-2-(6-chloropyridin-3-yl)propanoate

: 1199793-11-7
2-amino-1-(4-chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice

1.2: Cooling with ice

2.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 2 h / 20 °C

3.1: tetrahydrofuran / 1 h / Cooling with ice

4.1: acetic anhydride; dimethyl sulfoxide / 18 h / 20 °C / Cooling with ice

5.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C / Cooling with ice

With hydrogenchloride; lithium aluminium tetrahydride; sulfur trioxide pyridine complex; acetic anhydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide;

Reference yield:

: 55676-22-7
3-acetyl-6-chloropyridine

: 1199793-11-7
2-amino-1-(4-chloro-3-fluorophenyl)-2-(6-chloropyridin-3-yl)propan-1-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium hydroxide; ammonium chloride / methanol / 72 h / 20 °C

1.2: 2 h / Reflux; Cooling with ice

2.1: triethylamine / tetrahydrofuran / 36 h / Reflux

2.2: Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice

3.2: Cooling with ice

4.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 2 h / 20 °C

5.1: tetrahydrofuran / 1 h / Cooling with ice

6.1: acetic anhydride; dimethyl sulfoxide / 18 h / 20 °C / Cooling with ice

7.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C / Cooling with ice

With hydrogenchloride; ammonium hydroxide; lithium aluminium tetrahydride; sulfur trioxide pyridine complex; acetic anhydride; ammonium chloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dimethyl sulfoxide;