N-(2-Aminoethyl)piperazine

Base Information

• Chemical Name: N-(2-Aminoethyl)piperazine
• CAS No.: 140-31-8
• Deprecated CAS: 935701-76-1
• Molecular Formula: C6H15N3
• Molecular Weight: 129.205
• Hs Code.: Oral, rat LD50: 2140 mg/kg
• European Community (EC) Number: 205-411-0,608-228-8
• NSC Number: 38968
• UN Number: 2815
• UNII: I86052F9F6
• DSSTox Substance ID: DTXSID2021997
• Nikkaji Number: J35.446E
• Wikipedia: Aminoethylpiperazine
• Wikidata: Q3887815
• ChEMBL ID: CHEMBL209790
• Mol file: 140-31-8.mol

Synonyms:1-aminoethylpiperazine;1-MAEP;aminoethylpiperazine;aminoethylpiperazine, monoacetate;monoaminoethylpiperazine

Chemical Property of N-(2-Aminoethyl)piperazine

Chemical Property:

• Appearance/Colour: colorless liquid
• Vapor Pressure: 0.05 mm Hg ( 20 °C)
• Melting Point: -19 °C
• Refractive Index: 1.5000
• Boiling Point: 220 °C at 760 mmHg
• PKA: 10.11±0.10(Predicted)
• Flash Point: 93.3 °C
• PSA: 41.29000
• Density: 0.958 g/cm³
• LogP: -0.18270
• Storage Temp.: Store below +30°C.
• Sensitive.: Air Sensitive
• Solubility.: >1000g/l
• Water Solubility.: soluble
• XLogP3: -1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 129.126597491
• Heavy Atom Count: 9
• Complexity: 68.7
• Transport DOT Label: Corrosive Poison

Purity/Quality:

99% ^*data from raw suppliers

1-(2-Aminoethyl)piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 21/22-34-43-52/53
• Safety Statements: 26-36/37/39-45-61

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Piperazines
• Canonical SMILES: C1CN(CCN1)CCN
• Uses: Used for studying corrosion inhibition 1-(2-Aminoethyl)piperazine is utilized in a variety of reactions for studying corrosion inhibition, biological activity and metal ligand effects on catalysis. It is used for epoxy curing, surface activation, and as an asphalt additive. It is used in lube oil and fuel additives, mineral processing aids, polyamide resins, urethane chemicals, wet strength resins.

Technology Process of N-(2-Aminoethyl)piperazine

There total 37 articles about N-(2-Aminoethyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.3%

2,2’-(ethane-1,2-diylbis(azanediyl))diacetonitrile (18907-76-1) → aminoethylpiperazine (140-31-8) + triethylentetramine (112-24-3)

Guidance literature:

With hydrogen; at 120 ℃; under 150015 Torr; Concentration; Temperature; Pressure;

Reference yield:

ethylenediamine (107-15-3,85404-18-8) → piperazine (110-85-0) + 1,4-diaza-bicyclo[2.2.2]octane (280-57-9,88935-43-7) + aminoethylpiperazine (140-31-8)

Guidance literature:

In water; at 300 ℃; for 15h; Product distribution; Mechanism; other polyamines, amino alcohols and amino ethers;

Reference yield:

ethanolamine (141-43-5) → piperazine (110-85-0) + 1-(2-hydroxyethyl)piperazine (103-76-4) + aminoethylpiperazine (140-31-8) + ethylenediamine (107-15-3,85404-18-8) + 3-azapentane-1,5-diamine (111-40-0,98824-35-2)

Guidance literature:

With ammonia; hydrogen; In water; at 103 ℃; under 33806.7 Torr;

upstream raw materials:

2-(2-(piperazin-1-yl)ethyl)isoindoline-1,3-dione

tris-(2-chloroethyl)amine hydrochloride

ethyleneimine

piperazine

Downstream raw materials:

1,4-bis(2-aminoethyl)piperazine

1-<2-(2-aminoethyl)aminoethyl>piperazine

C₂₃H₂₅N₃O₃

C₂₄H₂₇N₃O₄

Refernces

• 1、 -. "MANUFACTURING METHOD OF CYCLIC ETHYLENE AMINES". Paragraph 0037; 0040. . Retrieved 2017/08/15.
• 2、 -. "Amination process for manufacturing amines using catalyst". Paragraph 0044-0049. . Retrieved 2014/08/07.