1,3-dibenzyloxy-2-propyl acetoacetate

Base Information

• Chemical Name: 1,3-dibenzyloxy-2-propyl acetoacetate
• CAS No.: 864251-39-8
• Molecular Formula: C₂₁H₂₄O₅
• Molecular Weight: 356.419
• Mol file: 864251-39-8.mol

Synonyms:1,3-dibenzyloxy-2-propyl acetoacetate

Chemical Property of 1,3-dibenzyloxy-2-propyl acetoacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-dibenzyloxy-2-propyl acetoacetate

There total 3 articles about 1,3-dibenzyloxy-2-propyl acetoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

4-methyleneoxetan-2-one (674-82-8,2130-41-8) + dibenzyl glycerol (6972-79-8) → 1,3-dibenzyloxy-2-propyl acetoacetate (864251-39-8)

Guidance literature:

With triethylamine; In toluene; at 90 ℃; for 1h;

Reference yield:

dibenzyl glycerol (6972-79-8) + 2,2,6-trimethyl-4H-1,3-dioxin-4-one (5394-63-8) → 1,3-dibenzyloxy-2-propyl acetoacetate (864251-39-8)

Guidance literature:

In xylene; at 140 ℃;

DOI:10.1016/S0040-4039(00)76684-6

Reference yield:

sodium phenyl-methanolate (20194-18-7) → 1,3-dibenzyloxy-2-propyl acetoacetate (864251-39-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / phenylmethanol / 1.5 h / Heating

2: xylene / 0.5 h / 150 °C

In xylene; benzyl alcohol; 1: Etherification / 2: Acylation;

DOI:10.1021/jo991211t

upstream raw materials:

dibenzyl glycerol

2,2,6-trimethyl-4H-1,3-dioxin-4-one

sodium phenyl-methanolate

4-methyleneoxetan-2-one

Downstream raw materials:

1,3-dibenzyloxy-2-propyl-diazoacetate

Refernces

• 1、 -. "1,4-DIARYL-DIHYDROPYRIMIDIN-2-ONES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS". Page/Page column 43. . Retrieved 2010/02/13.