(R)-(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(3-(2,5-dichloro-4-(hydroxymethyl)benzyl)thiazolidin-4-yl)methanone

Base Information

Chemical Name:(R)-(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(3-(2,5-dichloro-4-(hydroxymethyl)benzyl)thiazolidin-4-yl)methanone
CAS No.:1445983-24-3
Molecular Formula:C₂₃H₂₅Cl₂N₃O₂S
Molecular Weight:478.442
Hs Code.:

Synonyms:(R)-(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(3-(2,5-dichloro-4-(hydroxymethyl)benzyl)thiazolidin-4-yl)methanone

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Chemical Property of (R)-(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(3-(2,5-dichloro-4-(hydroxymethyl)benzyl)thiazolidin-4-yl)methanone

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Technology Process of (R)-(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(3-(2,5-dichloro-4-(hydroxymethyl)benzyl)thiazolidin-4-yl)methanone

There total 10 articles about (R)-(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(3-(2,5-dichloro-4-(hydroxymethyl)benzyl)thiazolidin-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1445985-48-7
1-cyclopropyl-4-[[(4R)-1,3-thiazolidin-4-yl]carbonyl]-1,2,3,4-tetrahydroquinoxaline

: 46052-84-0
2,5-dichloroterephthalic dicarboxaldehyde

: 1445983-24-3
(R)-(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(3-(2,5-dichloro-4-(hydroxymethyl)benzyl)thiazolidin-4-yl)methanone

Guidance literature:: 1-cyclopropyl-4-[[(4R)-1,3-thiazolidin-4-yl]carbonyl]-1,2,3,4-tetrahydroquinoxaline; 2,5-dichloroterephthalic dicarboxaldehyde; In 1,2-dichloro-ethane; for 1h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane;

Reference yield:

: 1124-05-6
1,4-dichloro-2,5-dimethylbenzene

: 1445983-24-3
(R)-(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(3-(2,5-dichloro-4-(hydroxymethyl)benzyl)thiazolidin-4-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; acetic anhydride; sulfuric acid; chromium(VI) oxide / 6 h / 0 - 20 °C

2: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane

With chromium(VI) oxide; sulfuric acid; acetic anhydride; sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane;
DOI:10.1021/acs.jmedchem.8b00308

Reference yield:

: 1445985-47-6
tert-butyl (4R)-4-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]-1,3-thiazolidine-3-carboxylate

: 1445983-24-3
(R)-(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(3-(2,5-dichloro-4-(hydroxymethyl)benzyl)thiazolidin-4-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water; 1,4-dioxane / 1 h / 20 °C

2: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane

With hydrogenchloride; sodium tris(acetoxy)borohydride; acetic acid; In 1,4-dioxane; water; 1,2-dichloro-ethane;
DOI:10.1021/acs.jmedchem.8b00308