N′-[2-cyano-5-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-3-hydroxyphenyl]-N,N-dimethylformamidine

Base Information

• Chemical Name: N′-[2-cyano-5-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-3-hydroxyphenyl]-N,N-dimethylformamidine
• CAS No.: 1609962-99-3
• Molecular Formula: C₁₂H₁₆N₄O₂S
• Molecular Weight: 280.351
• Mol file: 1609962-99-3.mol

Synonyms:N′-[2-cyano-5-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-3-hydroxyphenyl]-N,N-dimethylformamidine

Chemical Property of N′-[2-cyano-5-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-3-hydroxyphenyl]-N,N-dimethylformamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N′-[2-cyano-5-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-3-hydroxyphenyl]-N,N-dimethylformamidine

There total 6 articles about N′-[2-cyano-5-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-3-hydroxyphenyl]-N,N-dimethylformamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

N'-(5-bromo-2-cyano-3-fluorophenyl)-N,N-dimethylformamidine (1609963-01-0) → N′-[2-cyano-5-[[dimethyl(oxo)-λ6-sulfanylidene]amino]-3-hydroxyphenyl]-N,N-dimethylformamidine (1609962-99-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 71.0%

dimethylsulfoximine (1520-31-6) + N'-(5-bromo-2-cyano-3-fluorophenyl)-N,N-dimethylformamidine (1609963-01-0) → N′-[2-cyano-5-[[dimethyl(oxo)-λ6-sulfanylidene]amino]-3-hydroxyphenyl]-N,N-dimethylformamidine (1609962-99-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

2-amino-4-bromo-6-fluoro-benzonitrile (1279865-14-3) → N′-[2-cyano-5-[[dimethyl(oxo)-λ6-sulfanylidene]amino]-3-hydroxyphenyl]-N,N-dimethylformamidine (1609962-99-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1,1-dimethoxyethane / 2 h / 120 °C

2: caesium carbonate / 1,4-dioxane / 48 h / Reflux

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / 1,4-dioxane / 2 h / 80 °C

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1-dimethoxyethane; caesium carbonate; trifluoroacetic acid; johnphos; sodium t-butanolate; In 1,4-dioxane; dichloromethane;

upstream raw materials:

2-amino-4-bromo-6-fluoro-benzonitrile

4-bromo-2,6-difluorobenzonitrile

N'-(5-bromo-2-cyano-3-fluoro-phenyl)-N,N-dimethyl-formamidine

N'-(5-bromo-2-cyano-3-fluorophenyl)-N,N-dimethylformamidine

Downstream raw materials:

C₂₁H₂₁F₃N₄O₄S

C₂₀H₂₁FN₄O₄S

N'-[2-cyano-3-(difluoromethoxy)-5-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]phenyl]-N,N-dimethylformamidine