5-[3-(trifluoromethyl)phenyl]-N-(2,4-dioxoimidazolidin-1-yl)-2-furamide

Base Information

Chemical Name:5-[3-(trifluoromethyl)phenyl]-N-(2,4-dioxoimidazolidin-1-yl)-2-furamide
CAS No.:1326532-11-9
Molecular Formula:C₁₅H₁₀F₃N₃O₄
Molecular Weight:353.257
Hs Code.:

Synonyms:5-[3-(trifluoromethyl)phenyl]-N-(2,4-dioxoimidazolidin-1-yl)-2-furamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[3-(trifluoromethyl)phenyl]-N-(2,4-dioxoimidazolidin-1-yl)-2-furamide

Chemical Property:

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Technology Process of 5-[3-(trifluoromethyl)phenyl]-N-(2,4-dioxoimidazolidin-1-yl)-2-furamide

There total 4 articles about 5-[3-(trifluoromethyl)phenyl]-N-(2,4-dioxoimidazolidin-1-yl)-2-furamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 54022-99-0
5-(3-trifluoromethylphenyl)furan-2-carboxylic acid

: 2827-56-7
1-aminohydantoin hydrochloride

: 1326532-11-9
5-[3-(trifluoromethyl)phenyl]-N-(2,4-dioxoimidazolidin-1-yl)-2-furamide

Guidance literature:: With 4-methyl-morpholine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; water; at 20 ℃; for 19h;
DOI:10.1016/j.bmc.2012.08.062

Reference yield:

: 98-01-1
furfural

: 1326532-11-9
5-[3-(trifluoromethyl)phenyl]-N-(2,4-dioxoimidazolidin-1-yl)-2-furamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium nitrite; hydrogenchloride / water / 0.33 h / 0 - 110 °C

1.2: 0.25 h / 0 °C

1.3: 14 h / 0 - 20 °C

2.1: sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium chlorite / water; tert-butyl alcohol / 11 h / 20 °C

3.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; 4-methyl-morpholine / water; methanol / 19 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; sodium nitrite; In methanol; water; tert-butyl alcohol; 1.1: |Meerwein Arylation / 1.2: |Meerwein Arylation / 1.3: |Meerwein Arylation;
DOI:10.1016/j.bmc.2012.08.062

Reference yield:

: 52130-30-0
5-[3-(trifluoromethyl)phenyl]furan-2-carbaldehyde

: 1326532-11-9
5-[3-(trifluoromethyl)phenyl]-N-(2,4-dioxoimidazolidin-1-yl)-2-furamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium chlorite / water; tert-butyl alcohol / 11 h / 20 °C

2: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; 4-methyl-morpholine / water; methanol / 19 h / 20 °C

With 4-methyl-morpholine; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; water; tert-butyl alcohol;
DOI:10.1016/j.bmc.2012.08.062