2-phenethyl-2-(phenylsulfonyl)-1-thiacycloheptane S,S-dioxide

Base Information

• Chemical Name: 2-phenethyl-2-(phenylsulfonyl)-1-thiacycloheptane S,S-dioxide
• CAS No.: 130220-18-7
• Molecular Formula: C₂₀H₂₄O₄S₂
• Molecular Weight: 392.54
• Mol file: 130220-18-7.mol

Synonyms:2-phenethyl-2-(phenylsulfonyl)-1-thiacycloheptane S,S-dioxide

Chemical Property of 2-phenethyl-2-(phenylsulfonyl)-1-thiacycloheptane S,S-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-phenethyl-2-(phenylsulfonyl)-1-thiacycloheptane S,S-dioxide

There total 8 articles about 2-phenethyl-2-(phenylsulfonyl)-1-thiacycloheptane S,S-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Benzenesulfonyl-2-phenethyl-thiepane → 2-phenethyl-2-(phenylsulfonyl)-1-thiacycloheptane S,S-dioxide (130220-18-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 25 ℃; for 1h; Yield given;

Reference yield:

((3-phenylpropyl)sulfonyl)benzene (17494-61-0) → 2-phenethyl-2-(phenylsulfonyl)-1-thiacycloheptane S,S-dioxide (130220-18-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) hexamethylphosphoric triamide (HMPA), n-BuLi / 1.) THF, hexane, -78 deg C, 15 min, 2.) from -78 deg C to 25 deg C

2: 1.) hexamethylphosphoric triamide (HMPA), n-BuLi / 1.) THF, -78 deg C, 15 min, 2.) from -78 deg C to RT, 4 h

3: 82 percent / acetone; H₂O / 20 h / Ambient temperature

4: tetra-n-butylammonium fluoride ((TBA)F), 4-Angstroem molecular sieves / tetrahydrofuran / -78 - 25 °C

5: 87percent m-chloroperbenzoic acid (MCPBA) / CH₂Cl₂ / 1 h / 25 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; 4 A molecular sieve; tetrabutyl ammonium fluoride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; acetone;

Reference yield:

phenyl 3-phenylpropyl sulfide (30134-12-4) → 2-phenethyl-2-(phenylsulfonyl)-1-thiacycloheptane S,S-dioxide (130220-18-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 80percent m-chloroperbenzoic acid / CH₂Cl₂ / 25 °C

2: 1.) hexamethylphosphoric triamide (HMPA), n-BuLi / 1.) THF, hexane, -78 deg C, 15 min, 2.) from -78 deg C to 25 deg C

3: 1.) hexamethylphosphoric triamide (HMPA), n-BuLi / 1.) THF, -78 deg C, 15 min, 2.) from -78 deg C to RT, 4 h

4: 82 percent / acetone; H₂O / 20 h / Ambient temperature

5: tetra-n-butylammonium fluoride ((TBA)F), 4-Angstroem molecular sieves / tetrahydrofuran / -78 - 25 °C

6: 87percent m-chloroperbenzoic acid (MCPBA) / CH₂Cl₂ / 1 h / 25 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; 4 A molecular sieve; tetrabutyl ammonium fluoride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; acetone;

upstream raw materials:

((3-phenylpropyl)sulfonyl)benzene

1-Bromo-3-phenylpropane

phenyl 3-phenylpropyl sulfide

3-(trimethylsilyl)-1-phenyl-3-(phenylsulfonyl)propane

Downstream raw materials:

(2-(cyclohex-1-en-1-yl)ethyl)benzene