30134-12-4

Usage

Uses

Used in the Food Industry:
PHENYL 3-PHENYLPROPYL SULPHIDE is used as a flavoring agent for its distinctive garlic-like aroma, enhancing the taste profiles of various food products.
Used in the Cosmetic and Personal Care Products Industry:
In the realm of cosmetics and personal care, PHENYL 3-PHENYLPROPYL SULPHIDE serves as a fragrance ingredient, adding a pleasant scent to products while also potentially contributing to their antimicrobial properties.
Used in Health and Wellness Applications:
PHENYL 3-PHENYLPROPYL SULPHIDE is being investigated for its potential health benefits, such as antioxidant and antimicrobial properties, which could be harnessed in the development of health and wellness products.
Safety Considerations:
It is crucial to handle PHENYL 3-PHENYLPROPYL SULPHIDE with care due to its potential to cause skin and eye irritation. Additionally, it may pose risks if ingested or inhaled in large amounts, necessitating proper safety measures during its use and production.

InChI:InChI=1/C15H16S/c1-3-8-14(9-4-1)10-7-13-16-15-11-5-2-6-12-15/h1-6,8-9,11-12H,7,10,13H2

Upstream product

• 613245-32-2 1-(p-chlorophenylsulfinyl)-1-(p-chlorophenylthio)-3-phenylpropane 
• 74-88-4 methyl iodide 
• 122-97-4 3-Phenyl-1-propanol 
• 882-33-7 diphenyldisulfane 
• 174303-95-8 3-phenylpropyl diphenylphosphinite 
• 108-98-5 thiophenol 
• 4551-15-9 phenylthiotrimethylsilane 
• 122-72-5 3-phenylpropyl acetate 
• 637-59-2 1-Bromo-3-phenylpropane 
• 100-68-5 methyl-phenyl-thioether 
• 104-52-9 phenylpropyl chloride 
• 4119-41-9 1-iodo-3-phenylpropan 
• 613245-31-1 1-(phenylsulfinyl)-1-(phenylthio)-3-phenylpropane 
• 497181-12-1 1-phenyl-3-(4-trimethylsilylphenyl)thiopropane 

Downstream Products

• 37605-77-9 3-phenylpropyl phenyl sulfoxide 
• 103-65-1 phenylpropane 
• 65094-88-4 S-(3-phenylpropyl)-S-phenyl-N-(p-tolylsulfonyl)sulfimide 
• 65094-88-4 S-(3-phenylpropyl)-S-phenyl-N-(p-tolylsulfonyl)sulfimide 
• 882-33-7 diphenyldisulfane 
• 129169-33-1 2-(2-phenylethyl)-2-phenylthionaphtho<1,8-de>-1,3-dithiin 
• 129169-32-0 2-methylthio-2-(2-phenylethyl)-naphtho<1,8-de>-1,3-dithiin 
• 129169-48-8 2-Phenethylidene-naphtho[1,8-de][1,3]dithiine 
• 130220-24-5 bis<9-phenyl-7-(phenylsulfonyl)nonanyl> disulfide 
• 130220-15-4 3-(trimethylsilyl)-1-phenyl-3-(phenylsulfonyl)-9-p-(toluenethiosulfonyl)nonane 
• 130220-16-5 5-(trimethylsilyl)-7-phenyl-5-(phenylsulfonyl)heptanyl p-toluenesulfonyl disulfide 
• 130220-14-3 3-(trimethylsilyl)-1-phenyl-3-(phenylsulfonyl)-8-p-(toluenethiosulfonyl)octane 
• 130220-13-2 3-(trimethylsilyl)-1-phenyl-3-(phenylsulfonyl)-7-p-(toluenethiosulfonyl)heptane 
• 130220-22-3 3-(trimethylsilyl)-1-phenyl-3-(phenylsulfonyl)-9-<<2-(trimethylsilyl)ethyl>thio>nonane 

Relevant academic research and scientific papers

One-Pot Synthesis of N-Iodo Sulfoximines from Sulfides

This is the first report on the synthesis and characterization of N-iodo sulfoximines. The synthesis was designed as a room temperature one-pot cascade reaction from readily available sulfides as starting compounds, converted into sulfoximines by reaction with ammonium carbonate and (diacetoxyiodo)benzene, followed by iodination with N-iodosuccinimide or iodine in situ, in up to 90% isolated yields, also at a multigram scale. Iodination of aryls with N-iodo sulfoximines, oxidation, and conversion to N-SCF3 congeners have been demonstrated.

Nickel-Catalyzed Reductive Thiolation of Unactivated Alkyl Bromides and Arenesulfonyl Cyanides

The cross-electrophile coupling between unactivated alkyl bromides with arenesulfonyl cyanides catalyzed by Ni(acac)2under reductive conditions to form unsymmetrical sulfides is developed. This approach for sulfide synthesis is practical, relies on available, unfunctionalized materials such as alkyl (pseudo)halides, and is scalable. This catalytic strategy provides a complementary method for the preparation of unsymmetrical alkyl-aryl sulfides under mild conditions with good functional group tolerance.

Electroreductive Nickel-Catalyzed Thiolation: Efficient Cross-Electrophile Coupling for C?S Formation

Sulfur-containing molecules are of utmost topical importance towards the effective development of pharmaceuticals and functional materials. Herein, we present an efficient and mild electrochemical thiolation by cross-electrophile coupling of alkyl bromide

Photochemical Decarboxylative C(sp3)-X Coupling Facilitated by Weak Interaction of N-Heterocyclic Carbene

While N-hydroxyphthalimide (NHPI) ester has emerged as a powerful reagent as an alkyl radical source for a variety of C-C bond formations, the corresponding C(sp3)-N bond formation is still in its infancy. We demonstrate herein transition-metal-free decarboxylative C(sp3)-X bond formation enabled by the photochemical activity of the NHPI ester-NaI-NHC complex, giving primary C(sp3)-(N)phth, secondary C(sp3)-I, or tertiary C(sp3)-(meta C)phth coupling products. The primary C(sp3)-(N)phth coupling offers convenient access to primary amines.

Alkyl Sulfides as Promising Sulfur Sources: Metal-Free Synthesis of Aryl Alkyl Sulfides and Dialkyl Sulfides by Transalkylation of Simple Sulfides with Alkyl Halides

A site-selective metal-free dealkylative approach to synthesize aryl alkyl and symmetrical dialkyl sulfides has been developed. This procedure is convenient and has wide functional group tolerance giving rise to sulfides carrying various alkyl chains from simple alkyl sulfides and alkyl halides in good to excellent yields. This transalkylation proceeds by an ionic mechanism via sulfonium intermediates and it was proposed that dimethylacetamide (DMAC) may participate in part to promote the reaction.

Metal–organic framework MOF-199-catalyzed direct and one-pot synthesis of thiols, sulfides and disulfides from aryl halides in wet polyethylene glycols (PEG 400)

A highly porous metal–organic frame work Cu3 BTC2 (copper(II)-benzene-1,3,5-tricarboxylate) that is known as MOF-199 was synthesized from the reaction of 1,3,5-benzenetricarboxylic acid and Cu(OAc)2·H2O by a solvothermal method and characterized by several techniques including FT-IR, XRD, EDX and scanning electron microscopy. The MOF-199 used as an efficient catalyst for one-pot synthesis of thiols by domino reactions of aryl halides and thiourea, and subsequently conversion to aryl alkyl sulfides and diaryl disulfides in polyethylene glycols (PEGs). A variety of aryl alkyl sulfides can be obtained in good to excellent yields in a relatively short reaction time and in the presence of the trace amount of catalyst. Also, the catalyst can be separated from the reaction mixture by decanting, and be reused without significant degradation in catalytic activity.

Gold-Catalyzed Anti-Markovnikov Selective Hydrothiolation of Unactivated Alkenes

Despite the widespread use of transition-metal catalysts in organic synthesis, transition-metal-catalyzed reactions of organosulfur compounds, which are known as catalyst poisons, have been difficult. In particular, the transition-metal-catalyzed addition of organosulfur compounds to unactivated alkenes remains a challenge. A novel gold-catalyzed hydrothiolation of unactivated alkenes is presented, which proceeds effectively to give the anti-Markovnikov-selective adducts in good yields and in a regioselective manner.

Catalytic Iodination of the Aliphatic C-F Bond by YbI3(THF)3: Mechanistic Insight and Synthetic Utility

A facile iodination protocol of unactivated alkyl fluorides using catalytic amounts of YbI3(THF)3 in the presence of iodotrimethylsilane as a stoichiometric fluoride trapping agent is presented. 1H NMR spectroscopy demonstrates a two-step catalytic cycle where TMSI regenerates active YbI3(THF)3. Finally, the catalytic reaction is extended into a one-pot procedure to demonstrate a potential application of the method. Overall, the findings present a distinct strategy for C-F bond transformations in the presence of catalytic YbI3(THF)3.

One-Pot Copper-Catalysed Thioetherification of Aryl Halides Using Alcohols and Lawesson's Reagent in Diglyme

A new protocol for the thioetherification of structurally varied alcohols with aryl halides using Lawesson's reagent, catalysed by copper(I) iodide, and using diglyme as a safe solvent was developed. Using this method, the reactions of aryl halides proceeded efficiently, and the desired sulfides were obtained in high to excellent yields. The method uses alcohols as starting materials, which is a significant advantage over methods that start from thiols. Alcohols are widely commercially available in a much greater structural diversity than thiols, and they are also nontoxic and not foul-smelling. A reaction mechanism was proposed. A copper-catalysed method for the thioetherification of alcohols with aryl halides using Lawesson's reagent was developed.

Neutral sulfur nucleophiles: Synthesis of thioethers and thioesters by substitution reactions of N-heterocyclic carbene boryl sulfides and thioamides

Newly discovered boryl sulfides and N-borylthioamides are shown to serve as neutral sources of sulfur nucleophiles in substitutions reactions. For example, heating of diMe-Imd-BH(SPh)2 with benzyl bromides, primary bromides, or acid chlorides provides the corresponding thioethers or thioesters in high yields. Likewise, N-phenyltetrazole thioethers/esters are made from a readily available N-borylthionotetrazole. The formation of the boryl sulfide and its onward nucleophilic substitution can be telescoped down to a one-pot reaction whose components are an NHC-borane (NHC-BH3), a disulfide, and an electrophile.