1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl propionate

Base Information

Chemical Name:1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl propionate
CAS No.:1285548-21-1
Molecular Formula:C₂₆H₄₀ClN₃O₅
Molecular Weight:510.074
Hs Code.:

Synonyms:1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl propionate

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Chemical Property of 1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl propionate

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Technology Process of 1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl propionate

There total 10 articles about 1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1202400-18-7
1-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-3-(2-hydroxy-2-methylpropyl)urea

: 123-62-6
propionic acid anhydride

: 1285548-21-1
1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl propionate

Guidance literature:: dmap; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 324769-06-4
tert-butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate

: 1285548-21-1
1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl propionate

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 - -60 °C

1.2: 2 h / -78 - -60 °C

2.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

3.1: butanone; water / 20 °C / Reflux

4.1: sodium hydroxide / water

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C

5.2: 20 h / 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 2.5 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

7.2: 1 h

8.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere; Reflux

9.1: dmap / dichloromethane / 24 h / 20 °C

With hydrogenchloride; n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; dmap; benzotriazol-1-ol; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; acetonitrile; butanone;

Reference yield:

: 475085-56-4
4-(4-chloro-phenyl)-4-hydroxy-3,3-dimethyl-piperidine-1-carboxylic acid tert-butyl ester

: 1285548-21-1
1-(3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)ureido)-2-methylpropan-2-yl propionate

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

2.1: butanone; water / 20 °C / Reflux

3.1: sodium hydroxide / water

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C

4.2: 20 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 2.5 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

6.2: 1 h

7.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere; Reflux

8.1: dmap / dichloromethane / 24 h / 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; dmap; benzotriazol-1-ol; In 1,4-dioxane; dichloromethane; water; acetonitrile; butanone;