Acephate

Base Information

• Chemical Name: Acephate
• CAS No.: 30560-19-1
• Deprecated CAS: 115096-11-2
• Molecular Formula: C4H10NO3PS
• Molecular Weight: 183.168
• Hs Code.: 2930.90 Oral rat LD50: 945 mg/kg
• European Community (EC) Number: 250-241-2
• ICSC Number: 0748
• UN Number: 3018,2783
• UNII: 3Y417O444D
• DSSTox Substance ID: DTXSID8023846
• Nikkaji Number: J4.532B
• Wikipedia: Acephate
• Wikidata: Q2231923
• NCI Thesaurus Code: C163577
• Metabolomics Workbench ID: 54986
• ChEMBL ID: CHEMBL2133249
• Mol file: 30560-19-1.mol

Synonyms:acephate;O,S-dimethyl N-acetyl phosphoramidothioate;Orthene

Chemical Property of Acephate

Chemical Property:

• Appearance/Colour: White solid
• Vapor Pressure: 2.26 x 10-4 Pa (24 °C)
• Melting Point: 93 °C
• Refractive Index: 1.475
• Boiling Point: 2 °C
• PKA: 11.00±0.46(Predicted)
• Flash Point: 2°C
• PSA: 90.51000
• Density: 1.263 g/cm³
• LogP: 1.63090
• Storage Temp.: APPROX 4°C
• Water Solubility.: readily soluble
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 183.01190135
• Heavy Atom Count: 10
• Complexity: 172
• Transport DOT Label: Poison

Purity/Quality:

95%TC 30%EC ^*data from raw suppliers

Acephate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, F
• Hazard Codes: Xn,F
• Statements: 22-36-20/21/22-11
• Safety Statements: 2-36-36/37-16

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Pesticides -> Organophosphate Insecticides
• Canonical SMILES: CC(=O)NP(=O)(OC)SC
• Inhalation Risk: A harmful concentration of airborne particles can be reached quickly on spraying or when dispersed, especially if powdered.
• Effects of Short Term Exposure: The substance may cause effects on the nervous system and blood. This may result in cholinesterase inhibition. Medical observation is indicated. The effects may be delayed.
• General Description: Acephate is an organophosphorus insecticide detected using a highly sensitive and specific competitive indirect enzyme-linked immunosorbent assay (ciELISA). The assay demonstrated an IC50 of 25 ng/mL, a detection range of 5–140 ng/mL, and a low detection limit of 2 ng/mL, with minimal cross-reactivity to related compounds, making it suitable for monitoring acephate residues in environmental and agricultural samples.

Technology Process of Acephate

There total 7 articles about Acephate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

→ Acephate (30560-19-1)

Guidance literature:

Reference yield: 84.0%

acetamide (60-35-5) + phosphorochloridothioic acid,O,S-dimethyl ester (3711-50-0) → Acephate (30560-19-1)

Guidance literature:

With triethylamine; In toluene; at 5 - 30 ℃; for 5h; Reagent/catalyst; Temperature; Concentration;

Reference yield: 63.0%

acetamide (60-35-5) + dimethyl chlorothiophosphate (2524-03-0) → Acephate (30560-19-1)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 60 ℃;

DOI:10.1080/10426500902797079

upstream raw materials:

acetamide

dimethyl chlorothiophosphate

Mio

acetic anhydride

Downstream raw materials:

methanesulfonic acid

sec-butyl methanesulfonate

demethylthioacephate

Refernces

Development of an enzyme-linked immunosorbent assay for the detection of the organophosphorus insecticide acephate

10.1021/jf021020i

The study developed a competitive indirect enzyme-linked immunosorbent assay (ciELISA) for the detection of the organophosphorus insecticide acephate. Five different haptens mimicking acephate were synthesized and conjugated with carrier proteins to raise polyclonal antibodies in rabbits. These antibodies were then used to detect acephate in various samples. The study evaluated the effects of different assay conditions on sensitivity and found an IC50 value of 25 ng/mL for acephate, with a detection range of 5-140 ng/mL and a lowest detection limit of 2 ng/mL. The assay showed low cross-reactivities with structurally related insecticides, indicating high specificity. The chemicals used in the study included acephate, various haptens, bovine serum albumin (BSA), keyhole limpet hemocyanin (KLH), and organic solvents for assay optimization. These chemicals served to mimic the target analyte, carry the haptens in the assay, and adjust assay conditions to optimize sensitivity and specificity for detecting acephate residues in environmental and agricultural samples.

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