(S)-4-(1-hydroxyethyl)-2-chlorophenol

Base Information

• Chemical Name: (S)-4-(1-hydroxyethyl)-2-chlorophenol
• CAS No.: 1427170-22-6
• Molecular Formula: C₈H₉ClO₂
• Molecular Weight: 172.611
• Mol file: 1427170-22-6.mol

Synonyms:(S)-4-(1-hydroxyethyl)-2-chlorophenol

Chemical Property of (S)-4-(1-hydroxyethyl)-2-chlorophenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (S)-4-(1-hydroxyethyl)-2-chlorophenol

There total 8 articles about (S)-4-(1-hydroxyethyl)-2-chlorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-4-vinylphenol (45803-91-6) → (R)-4-(1-hydroxyethyl)-2-chlorophenol (1427170-32-8) + (S)-4-(1-hydroxyethyl)-2-chlorophenol (1427170-22-6)

Guidance literature:

With potassium hydrogencarbonate; at 30 ℃; for 24h; pH=Ca. 8.5; Reagent/catalyst; stereoselective reaction; Enzymatic reaction;

DOI:10.1002/anie.201207916

Reference yield:

2-chloro-4-vinylphenol (45803-91-6) → (S)-4-(1-hydroxyethyl)-2-chlorophenol (1427170-22-6)

Guidance literature:

With ferulic acid decarboxylase from Enterobacter sp. V₄₆E hydratase variant; water; In aq. phosphate buffer; isopropyl alcohol; at 25 ℃; for 0.283333h; pH=6; stereoselective reaction; Enzymatic reaction;

DOI:10.1021/acs.orglett.8b02058

Reference yield:

2-monochlorophenol (95-57-8) + sodium pyruvate (113-24-6) → (R)-4-(1-hydroxyethyl)-2-chlorophenol (1427170-32-8) + (S)-4-(1-hydroxyethyl)-2-chlorophenol (1427170-22-6) + 2-chloro-4-vinylphenol (45803-91-6)

Guidance literature:

With pyridoxal 5'-phosphate; ferulic acid decarboxylase from Enterobacter sp. V₄₆E hydratase variant; ferulic acid decarboxylase from Enterobacter sp; tyrosine ammonia lyase from Rhodobacter sphaeroides; tyrosine phenol lyase from Citrobacter freundii variant Met₃₇₉Val; water; ammonium chloride; In aq. phosphate buffer; isopropyl alcohol; at 30 ℃; for 24h; pH=8; stereoselective reaction; Enzymatic reaction;

DOI:10.1021/acs.orglett.8b02058

upstream raw materials:

4-hydroxy-3-chlorobenzaldehyde

2-chloro-4-vinylphenol

2-monochlorophenol

sodium pyruvate