(4-(tert-butoxycarbonyl-{4-[(2-chloro-7-methyl-quinazolin-4-ylamino)-methyl]-phenyl}-aminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester)

Base Information

Chemical Name:(4-(tert-butoxycarbonyl-{4-[(2-chloro-7-methyl-quinazolin-4-ylamino)-methyl]-phenyl}-aminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester)
CAS No.:1039736-87-2
Molecular Formula:C₃₂H₄₀ClN₅O₅
Molecular Weight:610.153
Hs Code.:

(4-(tert-butoxycarbonyl-{4-[(2-chloro-7-methyl-quinazolin-4-ylamino)-methyl]-phenyl}-aminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester)

Synonyms:(4-(tert-butoxycarbonyl-{4-[(2-chloro-7-methyl-quinazolin-4-ylamino)-methyl]-phenyl}-aminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester)

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Chemical Property of (4-(tert-butoxycarbonyl-{4-[(2-chloro-7-methyl-quinazolin-4-ylamino)-methyl]-phenyl}-aminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester)

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Technology Process of (4-(tert-butoxycarbonyl-{4-[(2-chloro-7-methyl-quinazolin-4-ylamino)-methyl]-phenyl}-aminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester)

There total 1 articles about (4-(tert-butoxycarbonyl-{4-[(2-chloro-7-methyl-quinazolin-4-ylamino)-methyl]-phenyl}-aminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 25171-19-1
7-methyl-2,4-dichloroquinazoline

: 4403-71-8
(4-aminomethyl)aniline

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 1039736-86-1
(4-{4-[(2-chloro-7-methyl-quinazolin-4-ylamino)-methyl]-phenylcarbamoyl}-piperidine-1-carboxylic acid tert-butyl ester)

: 1039736-87-2
(4-(tert-butoxycarbonyl-{4-[(2-chloro-7-methyl-quinazolin-4-ylamino)-methyl]-phenyl}-aminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester)

Guidance literature:: 7-methyl-2,4-dichloroquinazoline; (4-aminomethyl)aniline; With triethylamine; In chloroform; for 3h;

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; chloroform; at 20 ℃;

Reference yield: 59.0%

: 1039736-86-1
(4-{4-[(2-chloro-7-methyl-quinazolin-4-ylamino)-methyl]-phenylcarbamoyl}-piperidine-1-carboxylic acid tert-butyl ester)

: 1039736-87-2
(4-(tert-butoxycarbonyl-{4-[(2-chloro-7-methyl-quinazolin-4-ylamino)-methyl]-phenyl}-aminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester)

: 506-59-2
N,N-dimethylammonium chloride

: 1039736-51-0
tert-butyl 4-({[4-({[2-(dimethylamino)-7-methylquinazolin-4-yl]amino}methyl)phenyl]amino}carbonyl)piperidine-1-carboxylate

Guidance literature:: (4-{4-[(2-chloro-7-methyl-quinazolin-4-ylamino)-methyl]-phenylcarbamoyl}-piperidine-1-carboxylic acid tert-butyl ester); (4-(tert-butoxycarbonyl-{4-[(2-chloro-7-methyl-quinazolin-4-ylamino)-methyl]-phenyl}-aminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester); N,N-dimethylammonium chloride; In N,N-dimethyl-formamide; at 120 ℃; for 1 - 2h;

With sodium hydroxide; In chloroform; water; N,N-dimethyl-formamide;