tert-butyl 4-({[4-({[2-(dimethylamino)-7-methylquinazolin-4-yl]amino}methyl)phenyl]amino}carbonyl)piperidine-1-carboxylate

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Chemical Name:tert-butyl 4-({[4-({[2-(dimethylamino)-7-methylquinazolin-4-yl]amino}methyl)phenyl]amino}carbonyl)piperidine-1-carboxylate
CAS No.:1039736-51-0
Molecular Formula:C₂₉H₃₈N₆O₃
Molecular Weight:518.659
Hs Code.:

Synonyms:tert-butyl 4-({[4-({[2-(dimethylamino)-7-methylquinazolin-4-yl]amino}methyl)phenyl]amino}carbonyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-({[4-({[2-(dimethylamino)-7-methylquinazolin-4-yl]amino}methyl)phenyl]amino}carbonyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-({[4-({[2-(dimethylamino)-7-methylquinazolin-4-yl]amino}methyl)phenyl]amino}carbonyl)piperidine-1-carboxylate

There total 4 articles about tert-butyl 4-({[4-({[2-(dimethylamino)-7-methylquinazolin-4-yl]amino}methyl)phenyl]amino}carbonyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1039736-86-1
(4-{4-[(2-chloro-7-methyl-quinazolin-4-ylamino)-methyl]-phenylcarbamoyl}-piperidine-1-carboxylic acid tert-butyl ester)

: 124-40-3
dimethyl amine

: 1039736-51-0
tert-butyl 4-({[4-({[2-(dimethylamino)-7-methylquinazolin-4-yl]amino}methyl)phenyl]amino}carbonyl)piperidine-1-carboxylate

Guidance literature:: In tetrahydrofuran; at 100 ℃; for 0.5h; Microwave irradiation;
DOI:10.1016/j.bmcl.2009.07.070

Reference yield: 59.0%

: 1039736-86-1
(4-{4-[(2-chloro-7-methyl-quinazolin-4-ylamino)-methyl]-phenylcarbamoyl}-piperidine-1-carboxylic acid tert-butyl ester)

: 1039736-87-2
(4-(tert-butoxycarbonyl-{4-[(2-chloro-7-methyl-quinazolin-4-ylamino)-methyl]-phenyl}-aminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester)

: 506-59-2
N,N-dimethylammonium chloride

: 1039736-51-0
tert-butyl 4-({[4-({[2-(dimethylamino)-7-methylquinazolin-4-yl]amino}methyl)phenyl]amino}carbonyl)piperidine-1-carboxylate

Guidance literature:: (4-{4-[(2-chloro-7-methyl-quinazolin-4-ylamino)-methyl]-phenylcarbamoyl}-piperidine-1-carboxylic acid tert-butyl ester); (4-(tert-butoxycarbonyl-{4-[(2-chloro-7-methyl-quinazolin-4-ylamino)-methyl]-phenyl}-aminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester); N,N-dimethylammonium chloride; In N,N-dimethyl-formamide; at 120 ℃; for 1 - 2h;

With sodium hydroxide; In chloroform; water; N,N-dimethyl-formamide;

Reference yield:

: 25171-19-1
7-methyl-2,4-dichloroquinazoline

: 1039736-51-0
tert-butyl 4-({[4-({[2-(dimethylamino)-7-methylquinazolin-4-yl]amino}methyl)phenyl]amino}carbonyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / chloroform / 3 h

1.2: 20 °C

2.1: N,N-dimethyl-formamide / 1 - 2 h / 120 °C

With triethylamine; In chloroform; N,N-dimethyl-formamide;