1,1-dimethylethyl (3S)-3-[({2-[(methylamino)carbonyl]-6-nitrophenyl}amino)methyl]-1-pyrrolidinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl (3S)-3-[({2-[(methylamino)carbonyl]-6-nitrophenyl}amino)methyl]-1-pyrrolidinecarboxylate
CAS No.:1301189-83-2
Molecular Formula:C₁₈H₂₆N₄O₅
Molecular Weight:378.428
Hs Code.:

Synonyms:1,1-dimethylethyl (3S)-3-[({2-[(methylamino)carbonyl]-6-nitrophenyl}amino)methyl]-1-pyrrolidinecarboxylate

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Chemical Property of 1,1-dimethylethyl (3S)-3-[({2-[(methylamino)carbonyl]-6-nitrophenyl}amino)methyl]-1-pyrrolidinecarboxylate

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Technology Process of 1,1-dimethylethyl (3S)-3-[({2-[(methylamino)carbonyl]-6-nitrophenyl}amino)methyl]-1-pyrrolidinecarboxylate

There total 6 articles about 1,1-dimethylethyl (3S)-3-[({2-[(methylamino)carbonyl]-6-nitrophenyl}amino)methyl]-1-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 199175-10-5
1,1-dimethylethyl (3S)-3-(aminomethyl)-1-pyrrolidinecarboxylate

: 1301189-82-1
2-fluoro-N-methyl-3-nitrobenzamide

: 1301189-83-2
1,1-dimethylethyl (3S)-3-[({2-[(methylamino)carbonyl]-6-nitrophenyl}amino)methyl]-1-pyrrolidinecarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 90 ℃;

Reference yield:

: 317-46-4
2-fluoro-3-nitro-benzoic acid

: 1301189-83-2
1,1-dimethylethyl (3S)-3-[({2-[(methylamino)carbonyl]-6-nitrophenyl}amino)methyl]-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / Reflux

2.1: triethylamine / dichloromethane / 0.5 h / 20 °C

2.2: 0.5 h / -78 °C

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 90 °C

With thionyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane; dimethyl sulfoxide;

Reference yield:

: 101469-92-5,83220-73-9
(S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1301189-83-2
1,1-dimethylethyl (3S)-3-[({2-[(methylamino)carbonyl]-6-nitrophenyl}amino)methyl]-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C

2: N,N-dimethyl-formamide / 18 h / 100 °C / Inert atmosphere

3: hydrogen / ethanol; water / 3102.97 Torr

4: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 90 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;