4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-1-pyrazolyl)benzoic acid methyl ester

Base Information

• Chemical Name: 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-1-pyrazolyl)benzoic acid methyl ester
• CAS No.: 1027232-57-0
• Molecular Formula: C₁₉H₁₅F₃N₂O₂
• Molecular Weight: 360.336
• Mol file: 1027232-57-0.mol

Synonyms:4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-1-pyrazolyl)benzoic acid methyl ester

Chemical Property of 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-1-pyrazolyl)benzoic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-1-pyrazolyl)benzoic acid methyl ester

There total 6 articles about 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-1-pyrazolyl)benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.1%

4,4,4-trifluoro-1-(4-methylphenyl)butane-1,3-dione (720-94-5) + 4-hydrazinobenzoic acid methyl ester hydrochloride → 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-1-pyrazolyl)benzoic acid methyl ester (1027232-57-0)

Guidance literature:

In ethanol; for 5h; Reflux;

Reference yield: 34.0%

[4-(methoxycarbonyl)phenyl]hydrazine hydrochloride (6296-89-5) + 4,4,4-trifluoro-1-(4-methylphenyl)butane-1,3-dione (720-94-5) → 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-1-pyrazolyl)benzoic acid methyl ester (1027232-57-0)

Guidance literature:

In methanol; for 20h; regiospecific reaction; Reflux;

DOI:10.1002/cbdv.200800307

Reference yield:

methanol (67-56-1) + 4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzoic acid → 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-1-pyrazolyl)benzoic acid methyl ester (1027232-57-0)

Guidance literature:

methanol; 4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzoic acid; With thionyl chloride; at 0 - 20 ℃; for 15h; Inert atmosphere;

With sodium hydrogencarbonate; In methanol; water;

DOI:10.1016/j.ejmech.2011.05.024

upstream raw materials:

[4-(methoxycarbonyl)phenyl]hydrazine hydrochloride

4,4,4-trifluoro-1-(4-methylphenyl)butane-1,3-dione

methanol

para-methylacetophenone