5-ethoxycarbonyl-5-(4-methylphenylsulphonyl)-1,3-dimethyl-hexahydropyrimidine

Base Information

• Chemical Name: 5-ethoxycarbonyl-5-(4-methylphenylsulphonyl)-1,3-dimethyl-hexahydropyrimidine
• CAS No.: 107398-56-1
• Molecular Formula: C₁₆H₂₄N₂O₄S
• Molecular Weight: 340.444
• Mol file: 107398-56-1.mol

Synonyms:5-ethoxycarbonyl-5-(4-methylphenylsulphonyl)-1,3-dimethyl-hexahydropyrimidine

Chemical Property of 5-ethoxycarbonyl-5-(4-methylphenylsulphonyl)-1,3-dimethyl-hexahydropyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-ethoxycarbonyl-5-(4-methylphenylsulphonyl)-1,3-dimethyl-hexahydropyrimidine

There total 3 articles about 5-ethoxycarbonyl-5-(4-methylphenylsulphonyl)-1,3-dimethyl-hexahydropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.5%

1,3,5-trimethyl-1,3,5-triazacyclohexane (108-74-7) + (toluene-4-sulfonyl)-acetic acid ethyl ester (2850-19-3) → 5-ethoxycarbonyl-5-(4-methylphenylsulphonyl)-1,3-dimethyl-hexahydropyrimidine (107398-56-1)

Guidance literature:

With trifluoroacetic acid; In benzene; for 4h; Heating;

DOI:10.1016/S0040-4020(01)90615-5

Reference yield: 69.5%

1,3,5-trimethyl-1,3,5-triazacyclohexane (108-74-7) + 1,3,5-triethyl-1,3,5-triazacyclohexane (7779-27-3) + (toluene-4-sulfonyl)-acetic acid ethyl ester (2850-19-3) → 5-ethoxycarbonyl-5-(4-methylphenylsulphonyl)-1,3-dimethyl-hexahydropyrimidine (107398-56-1) + 5-ethoxycarbonyl-5-(4-methylphenylsulphonyl)-1,3-diethyl-hexahydropyrimidine (107398-57-2) + 3,7-dimethyl-1,5-di-(methylphenylsulphonyl)-3,7-diazabicyclo<3,3,1>nona-2,6-dione (107398-61-8) + 3,7-diethyl-1,5-di-(methylphenylsulphonyl)-3,7-diazabicyclo<3,3,1>nona-2,6-dione (107398-62-9)

Guidance literature:

Product distribution;

DOI:10.1016/S0040-4020(01)90615-5

Reference yield: 60.0%

1,3,5-trimethyl-1,3,5-triazacyclohexane (108-74-7) + (toluene-4-sulfonyl)-acetic acid ethyl ester (2850-19-3) + ethyl 3-oxo-3-phenylpropionate (94-02-0) + ethyl 2-cyanoacetate (105-56-6) + diethyl malonate (105-53-3) → 5-cyano-5-ethoxycarbonyl-1,3-dimethyl-hexahydropyrimidine (107398-53-8) + 5,5-diethoxycarbonyl-1,3-dimethyl-hexahydropyrimidine (107398-54-9) + 1,5-dicyano-3,7-dimethyl-diazabicyclo<3,3,1>nona-2,6-dione (107398-69-6) + 5-ethoxycarbonyl-5-(4-methylphenylsulphonyl)-1,3-dimethyl-hexahydropyrimidine (107398-56-1) + 1,5-diethoxycarbonyl-3,7-dimethyl-3,7-diazabicyclo<3,3,1>nona-2,6-dione (107398-58-3) + diethyl 3-benzoyl-1-methyl-6-phenyl-1,2,3,4-tetrahydropyridine-3,5-dicarboxylate (107398-65-2)

Guidance literature:

Product distribution; Mechanism;

DOI:10.1016/S0040-4020(01)90615-5

upstream raw materials:

1,3,5-trimethyl-1,3,5-triazacyclohexane

1,3,5-triethyl-1,3,5-triazacyclohexane

(toluene-4-sulfonyl)-acetic acid ethyl ester

ethyl 3-oxo-3-phenylpropionate