1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl)cyclopropane

Base Information

• Chemical Name: 1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl)cyclopropane
• CAS No.: 131544-74-6
• Molecular Formula: C₂₂H₁₈Cl₂O
• Molecular Weight: 369.29
• Mol file: 131544-74-6.mol

Synonyms:Benzene,1-(2,2-dichloro-1,3-diphenylcyclopropyl)-4-methoxy-, cis-; BDRM 72

Chemical Property of 1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl)cyclopropane

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 461°Cat760mmHg
• Flash Point: 107.2°C
• Density: 1.28g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl)cyclopropane

There total 12 articles about 1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl)cyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

chloroform (67-66-3,8013-54-5) + 4-(1,2-diphenylvinyl)anisole (72474-39-6,72474-43-2,1233-23-4) → (E)-1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl) cyclopropane (131544-74-6,131544-84-8,137070-57-6,137070-58-7) + (Z)-1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl) cyclopropane (131544-74-6,131544-84-8,137070-57-6,137070-58-7)

Guidance literature:

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; for 30h;

DOI:10.1021/jm00106a052

Reference yield: 12.0%

chloroform (67-66-3,8013-54-5) + 4-(1,2-diphenylvinyl)anisole (72474-39-6,72474-43-2,1233-23-4) → (E)-1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl) cyclopropane (131544-74-6,131544-84-8,137070-57-6,137070-58-7) + (Z)-1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl) cyclopropane (131544-74-6,131544-84-8,137070-57-6,137070-58-7)

Guidance literature:

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; for 30h;

DOI:10.1021/jm00106a052

Reference yield:

phenyl benzyl ketone (451-40-1) → (E)-1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl) cyclopropane (131544-74-6,131544-84-8,137070-57-6,137070-58-7)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 5.5 h / Heating

2: p-TSA / benzene / 2.5 h / Heating

3: 8.5 percent / aq. NaOH, TEBA / 72 h / Heating

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; toluene-4-sulfonic acid; In tetrahydrofuran; benzene;

DOI:10.1006/bioo.1996.0009

upstream raw materials:

chloroform

4-(1,2-diphenylvinyl)anisole

phenyl benzyl ketone

4-Methoxybenzophenone

Downstream raw materials:

(Z)-1,1-dichloro-2,3-diphenyl-2-(4-hydroxyphenyl)cyclopropane

Refernces

• 1、 Day, Billy W.,Magarian, Robert A.,Jain, Pramod T.,Pento, J. Thomas,Mousissian, Gorgin K.,Meyer, Karen L.. "Synthesis and Biological Evaluation of a Series of 1,1-Dichloro-2,2,3-triarylcyclopropanes as Pure Antiestrogens". . p. 842 - 851. Retrieved 2007/10/02.