triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate

Base Information

Chemical Name:triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate
CAS No.:127088-91-9
Molecular Formula:C₆H₁₅N*C₄₃H₄₇N₄O₁₃PS₂
Molecular Weight:1024.16
Hs Code.:

Synonyms:triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate

There total 19 articles about triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 118149-24-9
O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) hydrogenphosphonothioate

: 127088-91-9
triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate

Guidance literature:: With 2,6-dimethylpyridine; sulfur; In dichloromethane; toluene; for 0.5h; Ambient temperature;

Reference yield: 57.0%

: 21090-30-2
3'-O-acetylthymidine

: 128981-12-4
O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> H-phiosphonodithioate

: 127088-91-9
triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate

Guidance literature:: With iodine; In pyridine; Ambient temperature;
DOI:10.1016/S0040-4020(01)81775-0

Reference yield:

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 127088-91-9
triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate

Guidance literature:: Multi-step reaction with 6 steps

1: Et(i-Pr)2N / CHCl₃ / 0.17 h / Ambient temperature

2: CHCl₃ / 0.5 h / Ambient temperature

3: tetrazole / acetonitrile / 0.05 h

4: S₈ / acetonitrile; pyridine; CS₂

5: t-butylamine, pyridine

6: CH₂Cl₂; methanol

With pyridine; 1H-tetrazole; sulfur; tert-butylamine; N-ethyl-N,N-diisopropylamine; In pyridine; methanol; carbon disulfide; dichloromethane; chloroform; acetonitrile;