ethyl 4-{[1-(biphenyl-4-ylmethyl)-5-(1-cyclopropyl-1H-indol-5-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate

Base Information

Chemical Name:ethyl 4-{[1-(biphenyl-4-ylmethyl)-5-(1-cyclopropyl-1H-indol-5-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate
CAS No.:1332707-24-0
Molecular Formula:C₄₀H₃₇F₂N₃O₃
Molecular Weight:645.749
Hs Code.:

Synonyms:ethyl 4-{[1-(biphenyl-4-ylmethyl)-5-(1-cyclopropyl-1H-indol-5-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate

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Chemical Property of ethyl 4-{[1-(biphenyl-4-ylmethyl)-5-(1-cyclopropyl-1H-indol-5-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate

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Technology Process of ethyl 4-{[1-(biphenyl-4-ylmethyl)-5-(1-cyclopropyl-1H-indol-5-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate

There total 9 articles about ethyl 4-{[1-(biphenyl-4-ylmethyl)-5-(1-cyclopropyl-1H-indol-5-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 712-76-5
N-(4-phenyl)benzylamine

: 1332707-24-0
ethyl 4-{[1-(biphenyl-4-ylmethyl)-5-(1-cyclopropyl-1H-indol-5-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: potassium carbonate / tetrahydrofuran / 15 h / 20 °C

2: acetic acid; N-iodo-succinimide / 2 h / 70 °C

3: acetic acid; iron / ethanol; water / 2 h / 76 °C

4: dimethyl sulfoxide / 16 h / 20 °C

5: caesium carbonate / tert-butyl methyl ether; tetrahydrofuran / 20 °C

6: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 17 h / 20 °C

7: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 80 °C

8: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.67 h / 120 °C

9: dmap; sodium hexamethyldisilazane / copper diacetate / toluene / 95 °C / Inert atmosphere

With dmap; N-iodo-succinimide; sodium hexamethyldisilazane; iron; potassium carbonate; caesium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper diacetate; In tetrahydrofuran; ethanol; dichloromethane; tert-butyl methyl ether; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 315-14-0
1,3,5-trifluoro-2-nitrobenzene

: 1332707-24-0
ethyl 4-{[1-(biphenyl-4-ylmethyl)-5-(1-cyclopropyl-1H-indol-5-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: potassium carbonate / tetrahydrofuran / 15 h / 20 °C

2: acetic acid; N-iodo-succinimide / 2 h / 70 °C

3: acetic acid; iron / ethanol; water / 2 h / 76 °C

4: dimethyl sulfoxide / 16 h / 20 °C

5: caesium carbonate / tert-butyl methyl ether; tetrahydrofuran / 20 °C

6: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 17 h / 20 °C

7: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 80 °C

8: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.67 h / 120 °C

9: dmap; sodium hexamethyldisilazane / copper diacetate / toluene / 95 °C / Inert atmosphere

With dmap; N-iodo-succinimide; sodium hexamethyldisilazane; iron; potassium carbonate; caesium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper diacetate; In tetrahydrofuran; ethanol; dichloromethane; tert-butyl methyl ether; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1219741-26-0
1-(biphenyl-4-ylmethyl)-4.6-difluoro-5-iodo-2-(methylsulfonyl)-1H-benzimidazole

: 1332707-24-0
ethyl 4-{[1-(biphenyl-4-ylmethyl)-5-(1-cyclopropyl-1H-indol-5-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 80 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.67 h / 120 °C

3: dmap; sodium hexamethyldisilazane / copper diacetate / toluene / 95 °C / Inert atmosphere

With dmap; sodium hexamethyldisilazane; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper diacetate; In N,N-dimethyl-formamide; toluene;