3-({benzyloxycarbonyl-[2-(3-benzyl-phenyl)-2-oxo-ethyl]-amino}-methyl)-pyridine-2-carboxylic acid methyl ester

Base Information

Chemical Name:3-({benzyloxycarbonyl-[2-(3-benzyl-phenyl)-2-oxo-ethyl]-amino}-methyl)-pyridine-2-carboxylic acid methyl ester
CAS No.:500732-64-9
Molecular Formula:C₃₂H₃₀N₂O₅
Molecular Weight:522.601
Hs Code.:

Synonyms:3-({benzyloxycarbonyl-[2-(3-benzyl-phenyl)-2-oxo-ethyl]-amino}-methyl)-pyridine-2-carboxylic acid methyl ester

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Chemical Property of 3-({benzyloxycarbonyl-[2-(3-benzyl-phenyl)-2-oxo-ethyl]-amino}-methyl)-pyridine-2-carboxylic acid methyl ester

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Technology Process of 3-({benzyloxycarbonyl-[2-(3-benzyl-phenyl)-2-oxo-ethyl]-amino}-methyl)-pyridine-2-carboxylic acid methyl ester

There total 7 articles about 3-({benzyloxycarbonyl-[2-(3-benzyl-phenyl)-2-oxo-ethyl]-amino}-methyl)-pyridine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 64-17-5
ethanol

: 201230-82-2
carbon monoxide

: 500732-63-8
[2-(3-benzyl-phenyl)-2-oxo-ethyl]-(2-chloro-pyridin-3-ylmethyl)-carbamic acid benzyl ester

: 500732-64-9
3-({benzyloxycarbonyl-[2-(3-benzyl-phenyl)-2-oxo-ethyl]-amino}-methyl)-pyridine-2-carboxylic acid methyl ester

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; triethylamine; at 100 ℃; for 48h; under 12929 Torr;
DOI:10.1021/jm025553u

Reference yield:

: 89581-84-0
2-chloro-3-(chloromethyl)pyridine

: 500732-64-9
3-({benzyloxycarbonyl-[2-(3-benzyl-phenyl)-2-oxo-ethyl]-amino}-methyl)-pyridine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / LiN₃ / dimethylsulfoxide

2.1: 80 percent / H₂ / Pt/C / ethanol / 3 h

3.1: iPr₂NEt / acetonitrile / 1 h

3.2: 2.2 g / acetonitrile

4.1: 50 percent / Et₃N; Pd(PPh₃)2Cl₂ / 48 h / 100 °C / 12929 Torr

With bis-triphenylphosphine-palladium(II) chloride; lithium azide; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; platinum on activated charcoal; In ethanol; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm025553u

Reference yield:

: 42330-59-6
(2-chloropyrid-3-yl)methanol

: 500732-64-9
3-({benzyloxycarbonyl-[2-(3-benzyl-phenyl)-2-oxo-ethyl]-amino}-methyl)-pyridine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 98 percent / SOCl₂ / toluene; CH₂Cl₂ / 0 - 20 °C

2.1: 95 percent / LiN₃ / dimethylsulfoxide

3.1: 80 percent / H₂ / Pt/C / ethanol / 3 h

4.1: iPr₂NEt / acetonitrile / 1 h

4.2: 2.2 g / acetonitrile

5.1: 50 percent / Et₃N; Pd(PPh₃)2Cl₂ / 48 h / 100 °C / 12929 Torr

With bis-triphenylphosphine-palladium(II) chloride; thionyl chloride; lithium azide; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; platinum on activated charcoal; In ethanol; dichloromethane; dimethyl sulfoxide; toluene; acetonitrile;
DOI:10.1021/jm025553u