N-Benzyl-N-[2-(2-{benzyl-[2-(2-benzyloxy-ethoxy)-acetyl]-amino}-phenoxy)-phenyl]-2-(2-benzyloxy-ethoxy)-acetamide

Base Information

• Chemical Name: N-Benzyl-N-[2-(2-{benzyl-[2-(2-benzyloxy-ethoxy)-acetyl]-amino}-phenoxy)-phenyl]-2-(2-benzyloxy-ethoxy)-acetamide
• CAS No.: 181725-48-4
• Molecular Formula: C₄₈H₄₈N₂O₇
• Molecular Weight: 764.918
• Mol file: 181725-48-4.mol

Synonyms:N-Benzyl-N-[2-(2-{benzyl-[2-(2-benzyloxy-ethoxy)-acetyl]-amino}-phenoxy)-phenyl]-2-(2-benzyloxy-ethoxy)-acetamide

Chemical Property of N-Benzyl-N-[2-(2-{benzyl-[2-(2-benzyloxy-ethoxy)-acetyl]-amino}-phenoxy)-phenyl]-2-(2-benzyloxy-ethoxy)-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Benzyl-N-[2-(2-{benzyl-[2-(2-benzyloxy-ethoxy)-acetyl]-amino}-phenoxy)-phenyl]-2-(2-benzyloxy-ethoxy)-acetamide

There total 7 articles about N-Benzyl-N-[2-(2-{benzyl-[2-(2-benzyloxy-ethoxy)-acetyl]-amino}-phenoxy)-phenyl]-2-(2-benzyloxy-ethoxy)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis(2-aminophenyl)ether (24878-25-9) → N-Benzyl-N-[2-(2-{benzyl-[2-(2-benzyloxy-ethoxy)-acetyl]-amino}-phenoxy)-phenyl]-2-(2-benzyloxy-ethoxy)-acetamide (181725-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / Et₃N / CH₂Cl₂ / 2 h / Heating

2: 1.) NaH / 1.) THF, reflux, 2 h, 2.) THF, 16 h

With sodium hydride; triethylamine; In dichloromethane;

DOI:10.1055/s-1996-4319

Reference yield:

bis(2-nitrophenyl)ether (2217-65-4) → N-Benzyl-N-[2-(2-{benzyl-[2-(2-benzyloxy-ethoxy)-acetyl]-amino}-phenoxy)-phenyl]-2-(2-benzyloxy-ethoxy)-acetamide (181725-48-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / NH₂NH₂*H₂O / 10percent Pd/C / ethanol / 1 h / Heating

2: 76 percent / Et₃N / CH₂Cl₂ / 2 h / Heating

3: 1.) NaH / 1.) THF, reflux, 2 h, 2.) THF, 16 h

With sodium hydride; hydrazine hydrate; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1055/s-1996-4319

Reference yield:

2-hydroxynitrobenzene (88-75-5,78813-12-4) → N-Benzyl-N-[2-(2-{benzyl-[2-(2-benzyloxy-ethoxy)-acetyl]-amino}-phenoxy)-phenyl]-2-(2-benzyloxy-ethoxy)-acetamide (181725-48-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 77 percent / K₂CO₃ / dimethylsulfoxide / 16 h / 95 °C

2: 80 percent / NH₂NH₂*H₂O / 10percent Pd/C / ethanol / 1 h / Heating

3: 76 percent / Et₃N / CH₂Cl₂ / 2 h / Heating

4: 1.) NaH / 1.) THF, reflux, 2 h, 2.) THF, 16 h

With sodium hydride; potassium carbonate; hydrazine hydrate; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1055/s-1996-4319

upstream raw materials:

benzyl bromide

2-(2-Benzyloxy-ethoxy)-N-(2-{2-[2-(2-benzyloxy-ethoxy)-acetylamino]-phenoxy}-phenyl)-acetamide

bis(2-nitrophenyl)ether

2-Benzyloxyethanol

Downstream raw materials:

2-{2-[2-(Benzyl-{2-[2-(benzyl-{2-[2-({2-[2-(2-methoxy-acetylamino)-phenoxy]-phenylcarbamoyl}-methoxy)-ethoxy]-ethyl}-amino)-phenoxy]-phenyl}-amino)-ethoxy]-ethoxy}-N-{2-[2-(2-methoxy-acetylamino)-phenoxy]-phenyl}-acetamide

N-{2-[2-(2-Methoxy-acetylamino)-phenoxy]-phenyl}-2-(2-{2-[2-(2-{2-[2-({2-[2-(2-methoxy-acetylamino)-phenoxy]-phenylcarbamoyl}-methoxy)-ethoxy]-ethylamino}-phenoxy)-phenylamino]-ethoxy}-ethoxy)-acetamide

[2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-tert-butoxycarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid tert-butyl ester

[2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-carboxymethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid