[2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-tert-butoxycarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid tert-butyl ester

Base Information

• Chemical Name: [2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-tert-butoxycarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid tert-butyl ester
• CAS No.: 181725-54-2
• Molecular Formula: C₄₆H₆₀N₂O₉
• Molecular Weight: 784.99
• Mol file: 181725-54-2.mol

Synonyms:[2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-tert-butoxycarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid tert-butyl ester

Chemical Property of [2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-tert-butoxycarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-tert-butoxycarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid tert-butyl ester

There total 7 articles about [2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-tert-butoxycarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

bromoacetic acid tert-butyl ester (5292-43-3) + 2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-hydroxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethanol (181725-52-0) → [2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-tert-butoxycarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid tert-butyl ester (181725-54-2)

Guidance literature:

With sodium hydroxide; tetraethylammonium bromide; In dichloromethane; for 72h;

DOI:10.1055/s-1996-4319

Reference yield:

bis(2-aminophenyl)ether (24878-25-9) → [2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-tert-butoxycarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid tert-butyl ester (181725-54-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 76 percent / Et₃N / CH₂Cl₂ / 2 h / Heating

2: 1.) NaH / 1.) THF, reflux, 2 h, 2.) THF, 16 h

3: 48 percent / H₂ / 10percent Pd/C / ethanol / 16 h / Ambient temperature

4: 56 percent / LiAlH₄ / tetrahydrofuran / 16 h / Heating

5: 87 percent / Et₄NBr, aq. NaOH / CH₂Cl₂ / 72 h

With sodium hydroxide; lithium aluminium tetrahydride; tetraethylammonium bromide; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1055/s-1996-4319

Reference yield:

bis(2-nitrophenyl)ether (2217-65-4) → [2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-tert-butoxycarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid tert-butyl ester (181725-54-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 80 percent / NH₂NH₂*H₂O / 10percent Pd/C / ethanol / 1 h / Heating

2: 76 percent / Et₃N / CH₂Cl₂ / 2 h / Heating

3: 1.) NaH / 1.) THF, reflux, 2 h, 2.) THF, 16 h

4: 48 percent / H₂ / 10percent Pd/C / ethanol / 16 h / Ambient temperature

5: 56 percent / LiAlH₄ / tetrahydrofuran / 16 h / Heating

6: 87 percent / Et₄NBr, aq. NaOH / CH₂Cl₂ / 72 h

With sodium hydroxide; lithium aluminium tetrahydride; tetraethylammonium bromide; hydrogen; sodium hydride; hydrazine hydrate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1055/s-1996-4319

upstream raw materials:

bromoacetic acid tert-butyl ester

2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-hydroxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethanol

bis(2-nitrophenyl)ether

bis(2-aminophenyl)ether

Downstream raw materials:

[2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-chlorocarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetyl chloride

N-{2-[2-(2-Methoxy-acetylamino)-phenoxy]-phenyl}-2-(2-{2-[2-(2-{2-[2-({2-[2-(2-methoxy-acetylamino)-phenoxy]-phenylcarbamoyl}-methoxy)-ethoxy]-ethylamino}-phenoxy)-phenylamino]-ethoxy}-ethoxy)-acetamide

2-{2-[2-(Benzyl-{2-[2-(benzyl-{2-[2-({2-[2-(2-methoxy-acetylamino)-phenoxy]-phenylcarbamoyl}-methoxy)-ethoxy]-ethyl}-amino)-phenoxy]-phenyl}-amino)-ethoxy]-ethoxy}-N-{2-[2-(2-methoxy-acetylamino)-phenoxy]-phenyl}-acetamide

[2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-carboxymethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid