(E)-N-(p-methoxyphenylmethyl)-3-(p-methoxyphenylmethylidene)isoindolin-1-one

Base Information

Chemical Name:(E)-N-(p-methoxyphenylmethyl)-3-(p-methoxyphenylmethylidene)isoindolin-1-one
CAS No.:1209455-83-3
Molecular Formula:C₂₄H₂₁NO₃
Molecular Weight:371.436
Hs Code.:

Synonyms:(E)-N-(p-methoxyphenylmethyl)-3-(p-methoxyphenylmethylidene)isoindolin-1-one

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Chemical Property of (E)-N-(p-methoxyphenylmethyl)-3-(p-methoxyphenylmethylidene)isoindolin-1-one

Chemical Property:

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Technology Process of (E)-N-(p-methoxyphenylmethyl)-3-(p-methoxyphenylmethylidene)isoindolin-1-one

There total 4 articles about (E)-N-(p-methoxyphenylmethyl)-3-(p-methoxyphenylmethylidene)isoindolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403501-68-7
dimethyl 2-(4-methoxybenzyl)isoindolin-1-one-3-yl-phosphonate

: 123-11-5
4-methoxy-benzaldehyde

: 1209455-75-3
(Z)-N-(p-methoxyphenylmethyl)-3-(p-methoxyphenylmethylidene)isoindolin-1-one

: 1209455-83-3
(E)-N-(p-methoxyphenylmethyl)-3-(p-methoxyphenylmethylidene)isoindolin-1-one

Guidance literature:: dimethyl 2-(4-methoxybenzyl)isoindolin-1-one-3-yl-phosphonate; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.25h; Inert atmosphere;

4-methoxy-benzaldehyde; In tetrahydrofuran; at -78 ℃; for 1.25h; Overall yield = 85 %; stereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.08.040

Reference yield:

: 1209455-68-4
2-(2'-(p-methoxyphenyl)ethynyl)-N-(p-methoxyphenylmethyl)benzamide

: 1209455-75-3
(Z)-N-(p-methoxyphenylmethyl)-3-(p-methoxyphenylmethylidene)isoindolin-1-one

: 1209455-83-3
(E)-N-(p-methoxyphenylmethyl)-3-(p-methoxyphenylmethylidene)isoindolin-1-one

Guidance literature:: With phosphazene base-P₄-tert-butyl; In hexane; dimethyl sulfoxide; at 40 ℃; for 1.5h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/asia.200900342

Reference yield:

: 119-67-5
o-carboxybenzaldehyde

: 1209455-75-3
(Z)-N-(p-methoxyphenylmethyl)-3-(p-methoxyphenylmethylidene)isoindolin-1-one

: 1209455-83-3
(E)-N-(p-methoxyphenylmethyl)-3-(p-methoxyphenylmethylidene)isoindolin-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 0.25 h / 20 °C

1.2: 5 h / 50 °C

2.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

2.2: 1.25 h / -78 °C / Inert atmosphere

With n-butyllithium; In tetrahydrofuran; 2.1: |Horner-Wadsworth-Emmons Olefination / 2.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.tetlet.2012.08.040