2-bromo-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-4-methoxyphenol

Base Information

Chemical Name:2-bromo-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-4-methoxyphenol
CAS No.:347840-54-4
Molecular Formula:C₂₄H₂₇BrO₃Si
Molecular Weight:471.466
Hs Code.:

Synonyms:2-bromo-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-4-methoxyphenol

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Chemical Property of 2-bromo-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-4-methoxyphenol

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Technology Process of 2-bromo-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-4-methoxyphenol

There total 7 articles about 2-bromo-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-4-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 347840-66-8
[[2-bromo-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methoxyphenyl]methoxy](1,1-dimethylethyl)diphenylsilane

: 347840-54-4
2-bromo-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-4-methoxyphenol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.166667h;
DOI:10.1021/ol0159367

Reference yield:

: 1194-98-5
2,5-Dihydroxybenzaldehyde

: 347840-54-4
2-bromo-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-4-methoxyphenol

Guidance literature:: Multi-step reaction with 6 steps

1.1: Br₂ / CHCl₃ / 20 °C

2.1: 10.64 g / imidazole / CH₂Cl₂ / 0.25 h / 20 °C

3.1: NaH / tetrahydrofuran / 0.5 h

3.2: 72 percent / DMA / tetrahydrofuran / 6 h / 65 °C

4.1: 100 percent / NaBH₄ / ethanol / 0.5 h / 0 °C

5.1: 93 percent / imidazole / dimethylformamide / 2 h / 20 °C

6.1: TBAF / tetrahydrofuran / 0.17 h / 0 °C

With 1H-imidazole; sodium tetrahydroborate; tetrabutyl ammonium fluoride; bromine; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/ja021396c

Reference yield:

: 241127-72-0
2-bromo-3,6-dihydroxy-benzaldehyde

: 347840-54-4
2-bromo-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-4-methoxyphenol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 10.64 g / imidazole / CH₂Cl₂ / 0.25 h / 20 °C

2.1: NaH / tetrahydrofuran / 0.5 h

2.2: 72 percent / DMA / tetrahydrofuran / 6 h / 65 °C

3.1: 100 percent / NaBH₄ / ethanol / 0.5 h / 0 °C

4.1: 93 percent / imidazole / dimethylformamide / 2 h / 20 °C

5.1: TBAF / tetrahydrofuran / 0.17 h / 0 °C

With 1H-imidazole; sodium tetrahydroborate; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja021396c