2-Amino-5-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-1-methyl-1,5-dihydro-imidazol-4-one

Base Information

Chemical Name:2-Amino-5-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-1-methyl-1,5-dihydro-imidazol-4-one
CAS No.:313954-07-3
Molecular Formula:C₁₂H₁₃N₃O₂
Molecular Weight:231.254
Hs Code.:

Synonyms:2-Amino-5-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-1-methyl-1,5-dihydro-imidazol-4-one

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Chemical Property of 2-Amino-5-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-1-methyl-1,5-dihydro-imidazol-4-one

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Technology Process of 2-Amino-5-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-1-methyl-1,5-dihydro-imidazol-4-one

There total 1 articles about 2-Amino-5-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-1-methyl-1,5-dihydro-imidazol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 60-27-5
Creatinine

: 123-11-5
4-methoxy-benzaldehyde

: 313954-07-3
2-Amino-5-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-1-methyl-1,5-dihydro-imidazol-4-one

Guidance literature:: at 170 ℃; for 0.333333h;
DOI:10.1016/j.tetlet.2005.11.002

Reference yield: 98.0%

: 313954-07-3
2-Amino-5-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-1-methyl-1,5-dihydro-imidazol-4-one

: 74-88-4
methyl iodide

: 2-Imino-5-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-1,3-dimethyl-imidazolidin-4-one

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 20h;
DOI:10.1016/j.tetlet.2005.11.002

Reference yield:

: 313954-07-3
2-Amino-5-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-1-methyl-1,5-dihydro-imidazol-4-one

: [4-(1-hydroxy-4-oxo-cyclohexa-2,5-dienylmethyl)-4-(4-methoxy-benzyl)-1,3-dimethyl-5-oxo-imidazolidin-2-ylidene]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / dimethylformamide / 20 h / 20 °C

2: 100 percent / H₂ / Pd/C / methanol / 3 h / 20 °C / 760 Torr

3: 91 percent / LiHMDS / tetrahydrofuran / 1 h / 0 °C

4: 91 percent / n-BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C

5: 99 percent / H₂ / Pd/C / methanol / 3 h / 20 °C / 760 Torr

6: 56 percent / PIFA / acetonitrile; H₂O / 0.08 h / 0 °C

With n-butyllithium; hydrogen; bis-[(trifluoroacetoxy)iodo]benzene; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tetlet.2005.11.002