isopropyl 2-isopropoxy-4-methoxybenzoate

Base Information

• Chemical Name: isopropyl 2-isopropoxy-4-methoxybenzoate
• CAS No.: 1353891-99-2
• Molecular Formula: C₁₄H₂₀O₄
• Molecular Weight: 252.31
• Mol file: 1353891-99-2.mol

Synonyms:isopropyl 2-isopropoxy-4-methoxybenzoate

Chemical Property of isopropyl 2-isopropoxy-4-methoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of isopropyl 2-isopropoxy-4-methoxybenzoate

There total 2 articles about isopropyl 2-isopropoxy-4-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

isopropyl chloride (75-29-6) + 4-methoxysalicylic acid (2237-36-7) → isopropyl 2-isopropoxy-4-methoxybenzoate (1353891-99-2)

Guidance literature:

4-methoxysalicylic acid; With potassium carbonate; In N,N-dimethyl-formamide; for 0.25h;

isopropyl chloride; In N,N-dimethyl-formamide; for 4h; Reflux;

With potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 65.5h;

DOI:10.1039/c9cc07795b

Reference yield: 70.0%

4-methoxysalicylic acid (2237-36-7) + isopropyl bromide (75-26-3) → isopropyl 2-isopropoxy-4-methoxybenzoate (1353891-99-2)

Guidance literature:

4-methoxysalicylic acid; isopropyl bromide; With potassium carbonate; In N,N-dimethyl-formamide; for 31h; Reflux;

With potassium iodide; In N,N-dimethyl-formamide; for 17h;

Reference yield: 99.0%

isopropyl 2-isopropoxy-4-methoxybenzoate (1353891-99-2) → 2-isopropoxy-4-methoxybenzoic acid

Guidance literature:

With potassium hydroxide; In ethanol; at 95 ℃; for 3.5h;

DOI:10.1039/c9cc07795b

upstream raw materials:

4-methoxysalicylic acid

isopropyl bromide

isopropyl chloride

Downstream raw materials:

nutlin-3a

tert-butyl (1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethylcarbamate

N-((1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethyl)-3-oxopiperazine-1-carboxamide

Refernces

• 1、 Davis, Tyler A.,Vilgelm, Anna E.,Richmond, Ann,Johnston, Jeffrey N.. "Preparation of (-)-nutlin-3 using enantioselective organocatalysis at decagram scale". . p. 10605 - 10616. Retrieved 2013/11/19.