rac-N-[2-(3-bromo-phenyl)-2-tert-butoxycarbonylamino-propyl]-N-methyl-oxalamic acid ethyl ester

Base Information

Chemical Name:rac-N-[2-(3-bromo-phenyl)-2-tert-butoxycarbonylamino-propyl]-N-methyl-oxalamic acid ethyl ester
CAS No.:1353759-74-6
Molecular Formula:C₁₉H₂₇BrN₂O₅
Molecular Weight:443.338
Hs Code.:

Synonyms:rac-N-[2-(3-bromo-phenyl)-2-tert-butoxycarbonylamino-propyl]-N-methyl-oxalamic acid ethyl ester

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Chemical Property of rac-N-[2-(3-bromo-phenyl)-2-tert-butoxycarbonylamino-propyl]-N-methyl-oxalamic acid ethyl ester

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Technology Process of rac-N-[2-(3-bromo-phenyl)-2-tert-butoxycarbonylamino-propyl]-N-methyl-oxalamic acid ethyl ester

There total 7 articles about rac-N-[2-(3-bromo-phenyl)-2-tert-butoxycarbonylamino-propyl]-N-methyl-oxalamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 887913-45-3
rac-[1-(3-bromo-phenyl)-1-methyl-2-methylamino-ethyl]-carbamic acid tert-butyl ester

: 4755-77-5
Ethyl oxalyl chloride

: 1353759-74-6
rac-N-[2-(3-bromo-phenyl)-2-tert-butoxycarbonylamino-propyl]-N-methyl-oxalamic acid ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 3h;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1353759-74-6
rac-N-[2-(3-bromo-phenyl)-2-tert-butoxycarbonylamino-propyl]-N-methyl-oxalamic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonia; ammonium chloride / methanol / 96 h / 20 °C

2.1: hydrogenchloride / 96 h / Reflux

2.2: 20 °C / pH 8

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

4.1: sodium hydrogencarbonate / water; tetrahydrofuran / 15 h / 0 - 20 °C

4.2: pH 1 - 2 / Cooling with ice

5.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C

6.1: acetic acid / dichloromethane; tetrahydrofuran / 1 h / 20 °C

6.2: 5 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C / Cooling with ice

With hydrogenchloride; lithium aluminium tetrahydride; ammonia; sodium hydrogencarbonate; ammonium chloride; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 1183013-69-5
(RS)-2-amino-2-(3-bromo-phenyl)-propan-1-ol

: 1353759-74-6
rac-N-[2-(3-bromo-phenyl)-2-tert-butoxycarbonylamino-propyl]-N-methyl-oxalamic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / water; tetrahydrofuran / 15 h / 0 - 20 °C

1.2: pH 1 - 2 / Cooling with ice

2.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C

3.1: acetic acid / dichloromethane; tetrahydrofuran / 1 h / 20 °C

3.2: 5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C / Cooling with ice

With sodium hydrogencarbonate; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;