rac-[1-(3-bromo-phenyl)-1-methyl-2-methylamino-ethyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:rac-[1-(3-bromo-phenyl)-1-methyl-2-methylamino-ethyl]-carbamic acid tert-butyl ester
CAS No.:887913-45-3
Molecular Formula:C₁₅H₂₃BrN₂O₂
Molecular Weight:343.264
Hs Code.:

Synonyms:rac-[1-(3-bromo-phenyl)-1-methyl-2-methylamino-ethyl]-carbamic acid tert-butyl ester

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Chemical Property of rac-[1-(3-bromo-phenyl)-1-methyl-2-methylamino-ethyl]-carbamic acid tert-butyl ester

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Technology Process of rac-[1-(3-bromo-phenyl)-1-methyl-2-methylamino-ethyl]-carbamic acid tert-butyl ester

There total 6 articles about rac-[1-(3-bromo-phenyl)-1-methyl-2-methylamino-ethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 887913-44-2
rac-[1-(3-bromo-phenyl)-1-methyl-2-oxo-ethyl]-carbamic acid tert-butyl ester

: 74-89-5
methylamine

: 887913-45-3
rac-[1-(3-bromo-phenyl)-1-methyl-2-methylamino-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: rac-[1-(3-bromo-phenyl)-1-methyl-2-oxo-ethyl]-carbamic acid tert-butyl ester; methylamine; With acetic acid; In tetrahydrofuran; dichloromethane; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; dichloromethane; at 20 ℃; for 5h;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 887913-45-3
rac-[1-(3-bromo-phenyl)-1-methyl-2-methylamino-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonia; ammonium chloride / methanol / 96 h / 20 °C

2.1: hydrogenchloride / 96 h / Reflux

2.2: 20 °C / pH 8

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

4.1: sodium hydrogencarbonate / water; tetrahydrofuran / 15 h / 0 - 20 °C

4.2: pH 1 - 2 / Cooling with ice

5.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C

6.1: acetic acid / dichloromethane; tetrahydrofuran / 1 h / 20 °C

6.2: 5 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; ammonia; sodium hydrogencarbonate; ammonium chloride; Dess-Martin periodane; acetic acid; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 1183013-69-5
(RS)-2-amino-2-(3-bromo-phenyl)-propan-1-ol

: 887913-45-3
rac-[1-(3-bromo-phenyl)-1-methyl-2-methylamino-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / water; tetrahydrofuran / 15 h / 0 - 20 °C

1.2: pH 1 - 2 / Cooling with ice

2.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C

3.1: acetic acid / dichloromethane; tetrahydrofuran / 1 h / 20 °C

3.2: 5 h / 20 °C

With sodium hydrogencarbonate; Dess-Martin periodane; acetic acid; In tetrahydrofuran; dichloromethane; water;