Hemin

Base Information

• Chemical Name: Hemin
• CAS No.: 16009-13-5
• Molecular Formula: C34H32ClFeN4O4
• Molecular Weight: 651.952
• Hs Code.: 29349990
• Mol file: 16009-13-5.mol

Synonyms:Protoferriheme;Ferrate(2-),chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kN21,kN22,kN23,kN24]-, hydrogen (1:2), (SP-5-13)-;Protohemin chloride;Teichmann's crystals;Ferrate(2-),chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kN21,kN22,kN23,kN24]-, dihydrogen, (SP-5-13)-(9CI);Iron, chloro[dihydrogen3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)]- (8CI);Protohemin IX (6CI);1,3,5,8-Tetramethyl-2,4-divinylporphine-6,7-dipropionicacid ferrichloride;Chlorohemin;Chloroprotoferriheme;Ferric hemin;Ferriheme chloride;Ferriporphyrin chloride;Ferriprotoporphyrin;Ferriprotoporphyrin IX chloride;Hemin IX;Iron(III) protoporphyrin chloride;Panhematin;Chloroprotoporphyrin IX iron(III);

Chemical Property of Hemin

Chemical Property:

• Appearance/Colour: Dark purple crystalline powder
• Melting Point: 300 °C
• PSA: 109.18000
• LogP: 4.29920
• Storage Temp.: 2-8°C
• Solubility.: 1.4 M NaOH: soluble25mg/mL
• Water Solubility.: practically insoluble

Purity/Quality:

98%,99%, ^*data from raw suppliers

HeminChloride(Technicalgrade) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-22-36-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Identification of blood stains, biochemical research, complexing agent. Hemin is used in cellular protection and control mechanism. It stimulates the synthesis of globulin. It is also used to study the bacterial strains and growth conditions, in the short-term colony assays and cell transfections. Further, it is used to treat the symptoms of various porphyrias. In addition, it is used in the preparation of agar medium for the bacteria culture. Hemin is used for the following applications:To study bacterial strains and growth conditionsUsed in short-term colony assays (the culture medium consists of hemin along with other components)Cell transfectionsIt may be used in β-hematin formation assay for analyzing the inhibitory activity of MMV (Medicines for Malaria Venture) Malaria Box compounds against the formation of β-hematin.

Technology Process of Hemin

There total 2 articles about Hemin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

iron(III) chloride + protoporphyrin IX (553-12-8) → iron(III) protoporphyrin IX chloride (13496-05-4,16009-13-5)

Guidance literature:

In water; dimethyl sulfoxide; for 12h;

DOI:10.1002/chem.201402632

Reference yield:

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → (SP-5-13)-chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-ferrate(2-), dihydrogen (16009-13-5)

Guidance literature:

for 24h; radioactivity investigations with duck blood;

Reference yield: 99.0%

methanol (67-56-1) + hemin (13496-05-4,16009-13-5) → 3,3'-(3,7,12,17-tetramethyl-8,13-divinyl-21H,23H-porphine-2,18-diyl)-bis-propionic acid dimethyl ester (5522-66-7,6164-53-0)

Guidance literature:

With pyridine; diammonium iron(II) sulfate hexahydrate; acetyl chloride; In dichloromethane; for 1h; Cooling;

DOI:10.1016/j.mencom.2020.03.027

upstream raw materials:

L-glutamic acid

protoporphyrin IX

Downstream raw materials:

heme b

ClFe(C(N)C(CH₃)C(CHCH₂)CCH)2(C(N)C(CH₃)C(CH₂CH₂COOCH₃)CCH)2

iron(III) protophosphyrin IX monomethyl ester chloride

iron(III) protophosphyrin IX monomethyl ester chloride

Refernces

• 1、 Franck, Burchard,Bruse, Manfred,Dahmer, Juergen. "Haem-Biosynthese aus L-Glutaminsaeure". . p. 1000 - 1001. Retrieved 2007/10/02.