methyl [3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetate

Base Information

Chemical Name:methyl [3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetate
CAS No.:1350468-91-5
Molecular Formula:C₂₆H₂₃F₃N₂O₄
Molecular Weight:484.475
Hs Code.:

Synonyms:methyl [3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetate

Suppliers and Price of methyl [3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl [3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetate

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of methyl [3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetate

There total 8 articles about methyl [3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 594844-72-1
(4-amino-3-dimethylcarbamoylphenyl)acetic acid methyl ester

: 180340-74-3
4'-trifluoromethylbiphenyl-2-carbonyl chloride

: 1350468-91-5
methyl [3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetate

Guidance literature:: With triethylamine; In 1,2-dichloro-ethane; at 20 ℃; for 0.166667h;

Reference yield:

: 84392-17-6
4'-(trifluoromethyl)-2-biphenylcarboxylic acid

: 1350468-91-5
methyl [3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / 1,2-dichloro-ethane / 2.5 h / 20 °C

2: triethylamine / 1,2-dichloro-ethane / 0.17 h / 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In 1,2-dichloro-ethane;

Reference yield:

: 480451-75-0
5-chloro-N,N-dimethyl-2-nitrobenzamide

: 1350468-91-5
methyl [3-(dimethylcarbamoyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)phenyl]acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

1.2: 3 h / 120 °C

2.1: hydrogenchloride; water / 3 h / Reflux

3.1: acetyl chloride / 3 h / 0 - 20 °C

4.1: hydrogen / 5%-palladium/activated carbon / toluene; tetrahydrofuran / 20 °C / 37503.8 Torr

5.1: triethylamine / 1,2-dichloro-ethane / 0.17 h / 20 °C

With hydrogenchloride; water; hydrogen; sodium hydride; triethylamine; acetyl chloride; 5%-palladium/activated carbon; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; mineral oil;