(S)-2-[2-(1-methyl-2-piperidinyl)ethyl]benzenamine (1R,3S)-(+)-camphoric acid salt

Base Information

• Chemical Name: (S)-2-[2-(1-methyl-2-piperidinyl)ethyl]benzenamine (1R,3S)-(+)-camphoric acid salt
• CAS No.: 62414-73-7
• Molecular Formula: C₁₀H₁₆O₄*C₁₄H₂₂N₂
• Molecular Weight: 418.577
• Mol file: 62414-73-7.mol

Synonyms:(S)-2-[2-(1-methyl-2-piperidinyl)ethyl]benzenamine (1R,3S)-(+)-camphoric acid salt

Chemical Property of (S)-2-[2-(1-methyl-2-piperidinyl)ethyl]benzenamine (1R,3S)-(+)-camphoric acid salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[2-(1-methyl-2-piperidinyl)ethyl]benzenamine (1R,3S)-(+)-camphoric acid salt

There total 8 articles about (S)-2-[2-(1-methyl-2-piperidinyl)ethyl]benzenamine (1R,3S)-(+)-camphoric acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

2-[2-(1-methyl-2-piperidinyl)ethyl]-benzenamine 4-methylbenzenesulfonate (951155-19-4) + D-(+)-camphoric acid (124-83-4) → (S)-2-[2-(1-methyl-2-piperidinyl)ethyl]benzenamine (1R,3S)-(+)-camphoric acid salt (62414-73-7)

Guidance literature:

2-[2-(1-methyl-2-piperidinyl)ethyl]-benzenamine 4-methylbenzenesulfonate; With sodium hydroxide; In Isopropyl acetate; water; Industrial scale;

D-(+)-camphoric acid; In ethanol; isopropyl alcohol; at 65 ℃; Industrial scale;

DOI:10.1021/op5003402

Reference yield: 40.6%

D-(+)-camphoric acid (124-83-4) + 2-(ortho-aminophenethyl)-1-methylpiperidine (37611-80-6) → (S)-2-[2-(1-methyl-2-piperidinyl)ethyl]benzenamine (1R,3S)-(+)-camphoric acid salt (62414-73-7)

Guidance literature:

In Isopropyl acetate; isopropyl alcohol; at 20 - 85 ℃; for 2.58333h; Product distribution / selectivity;

Reference yield:

D-(+)-camphoric acid (124-83-4) + 2-(ortho-aminophenethyl)-1-methylpiperidine (37611-80-6) → (R)-2-[2-(1-methyl-2-piperidinyl)ethyl]-benzenamine (1R,3S)-(+)-camphoric acid salt + (S)-2-[2-(1-methyl-2-piperidinyl)ethyl]benzenamine (1R,3S)-(+)-camphoric acid salt (62414-73-7)

Guidance literature:

In ethanol; isopropyl alcohol; at 0 - 75 ℃; for 3.25 - 3.5h; Purification / work up; Resolution of racemate; Seed crystals;

upstream raw materials:

D-(+)-camphoric acid

2-(ortho-aminophenethyl)-1-methylpiperidine

2-[2-(1-methyl-2-piperidinyl)ethyl]-benzenamine 4-methylbenzenesulfonate

2-(o-nitrostyryl)-pyridine

Downstream raw materials:

(S)-2-[2-(1-methyl-2-piperidinyl)ethyl]-benzenamine