Methyl 4-phenylpiperidine-4-carboxylate hydrochloride

Base Information

• Chemical Name: Methyl 4-phenylpiperidine-4-carboxylate hydrochloride
• CAS No.: 83898-15-1
• Molecular Formula: C13H17 N O2 . Cl H
• Molecular Weight: 255.744
• European Community (EC) Number: 281-223-2
• DSSTox Substance ID: DTXSID60232784
• Mol file: 83898-15-1.mol

Synonyms:Methyl 4-phenylpiperidine-4-carboxylate hydrochloride;83898-15-1;Methyl 4-phenylpiperidine-4-carboxylate HCl;EINECS 281-223-2;methyl 4-phenylpiperidine-4-carboxylate;hydrochloride;methyl4-phenylpiperidine-4-carboxylatehydrochloride;SCHEMBL2636222;DTXSID60232784;VSNWCTNBFRAGLG-UHFFFAOYSA-N;4-Phenyl-piperidine-4-carboxylic acid methyl ester hydrochloride;4-phenyl-piperidine-4-carboxylic acid methyl-ester hydrochloride

Chemical Property of Methyl 4-phenylpiperidine-4-carboxylate hydrochloride

Chemical Property:

• Vapor Pressure: 0.00037mmHg at 25°C
• Boiling Point: 318.1°C at 760 mmHg
• Flash Point: 146.2°C
• PSA: 38.33000
• LogP: 2.61160
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 255.1026065
• Heavy Atom Count: 17
• Complexity: 240

Purity/Quality:

99% ^*data from raw suppliers

METHYL 4-PHENYLPIPERIDINE-4-CARBOXYLATE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1(CCNCC1)C2=CC=CC=C2.Cl

Technology Process of Methyl 4-phenylpiperidine-4-carboxylate hydrochloride

There total 3 articles about Methyl 4-phenylpiperidine-4-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-phenylpiperidine-4-carboxylic acid hydrochloride (53484-76-7) → 4-phenyl-piperidine-4-carboxylic acid methyl ester; hydrochloride (83898-15-1)

Guidance literature:

With thionyl chloride; In methanol; diethyl ether;

Reference yield:

4-Phenyl1-piperidinecarboxylic acid → 4-phenyl-piperidine-4-carboxylic acid methyl ester; hydrochloride (83898-15-1)

Guidance literature:

With thionyl chloride; In methanol; toluene;

Reference yield:

methanol (67-56-1) + 4-phenyl-piperidine-4-carboxylic acid (3627-45-0) → 4-phenyl-piperidine-4-carboxylic acid methyl ester; hydrochloride (83898-15-1)

Guidance literature:

With thionyl chloride; at 20 ℃;

upstream raw materials:

methanol

4-phenyl-piperidine-4-carboxylic acid

4-phenylpiperidine-4-carboxylic acid hydrochloride

Downstream raw materials:

1-(3-oxo-3-phenyl-propyl)-4-phenyl-piperidine-4-carboxylic acid methyl ester; hydrochloride

1-(3-oxo-3-p-tolyl-propyl)-4-phenyl-piperidine-4-carboxylic acid methyl ester; hydrochloride

1-[3-(4-ethyl-phenyl)-3-oxo-propyl]-4-phenyl-piperidine-4-carboxylic acid methyl ester; hydrochloride

1-[3-(2-hydroxy-phenyl)-3-oxo-propyl]-4-phenyl-piperidine-4-carboxylic acid methyl ester; hydrochloride

Refernces

• 1、 -. "Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds". Page 92. . Retrieved 2010/02/07.
• 2、 -. "SUBSTITUTED PYRROLIDIN-3-YL-ALKYL-PIPERIDINES". . . Retrieved 2008/06/13.