N-[3-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]pyridin-2-ylmethyl]cyclopropanecarboxamide

Base Information

Chemical Name:N-[3-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]pyridin-2-ylmethyl]cyclopropanecarboxamide
CAS No.:950481-85-3
Molecular Formula:C₂₀H₁₅Cl₃F₃N₃O₂
Molecular Weight:492.712
Hs Code.:

Synonyms:N-[3-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]pyridin-2-ylmethyl]cyclopropanecarboxamide

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Chemical Property of N-[3-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]pyridin-2-ylmethyl]cyclopropanecarboxamide

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Technology Process of N-[3-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]pyridin-2-ylmethyl]cyclopropanecarboxamide

There total 5 articles about N-[3-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]pyridin-2-ylmethyl]cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67492-50-6
(3,5-dichlorophenyl)boronic acid

: 950481-85-3
N-[3-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]pyridin-2-ylmethyl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 3 h / Heating / reflux

2.1: N-chloro-succinimide / 1,2-dimethoxyethane / 4 h / 70 °C

2.2: 20 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl acetamide / 4.5 h / 80 - 120 °C

4.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / methanol; water / 2.5 h / 20 °C / 760.05 Torr

5.1: triethylamine / chloroform / 1 h / 0 - 20 °C

With hydrogenchloride; N-chloro-succinimide; hydrogen; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; chloroform; N,N-dimethyl acetamide; water;

Reference yield:

: 950482-65-2
3-(6-aminomethyl-5-chloro-3-pyridyl)-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 950481-85-3
N-[3-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]pyridin-2-ylmethyl]cyclopropanecarboxamide

Guidance literature:: With triethylamine; In chloroform; at 0 - 20 ℃; for 1h;

Reference yield:

: 864725-22-4
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 950481-85-3
N-[3-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]pyridin-2-ylmethyl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-chloro-succinimide / 1,2-dimethoxyethane / 4 h / 70 °C

1.2: 20 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl acetamide / 4.5 h / 80 - 120 °C

3.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / methanol; water / 2.5 h / 20 °C / 760.05 Torr

4.1: triethylamine / chloroform / 1 h / 0 - 20 °C

With hydrogenchloride; N-chloro-succinimide; hydrogen; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5%-palladium/activated carbon; In methanol; 1,2-dimethoxyethane; chloroform; N,N-dimethyl acetamide; water;