5-(3,5-dichlorophenyl)-3-(5,6-dichloro-3-pyridyl)-5-trifluoromethyl-4,5-dihydroisoxazole

Base Information

Chemical Name:5-(3,5-dichlorophenyl)-3-(5,6-dichloro-3-pyridyl)-5-trifluoromethyl-4,5-dihydroisoxazole
CAS No.:950482-85-6
Molecular Formula:C₁₅H₇Cl₄F₃N₂O
Molecular Weight:430.041
Hs Code.:

Synonyms:5-(3,5-dichlorophenyl)-3-(5,6-dichloro-3-pyridyl)-5-trifluoromethyl-4,5-dihydroisoxazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(3,5-dichlorophenyl)-3-(5,6-dichloro-3-pyridyl)-5-trifluoromethyl-4,5-dihydroisoxazole

Chemical Property:

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Technology Process of 5-(3,5-dichlorophenyl)-3-(5,6-dichloro-3-pyridyl)-5-trifluoromethyl-4,5-dihydroisoxazole

There total 6 articles about 5-(3,5-dichlorophenyl)-3-(5,6-dichloro-3-pyridyl)-5-trifluoromethyl-4,5-dihydroisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67492-50-6
(3,5-dichlorophenyl)boronic acid

: 950482-85-6
5-(3,5-dichlorophenyl)-3-(5,6-dichloro-3-pyridyl)-5-trifluoromethyl-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 3 h / Heating / reflux

2.1: N-chloro-succinimide / 1,2-dimethoxyethane / 4 h / 70 °C

2.2: 20 h / 20 °C

With N-chloro-succinimide; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; water;

Reference yield:

: 864725-22-4
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 261625-62-1
5,6-dichloronicotinaldehyde oxime

: 950482-85-6
5-(3,5-dichlorophenyl)-3-(5,6-dichloro-3-pyridyl)-5-trifluoromethyl-4,5-dihydroisoxazole

Guidance literature:: With sodium hypochlorite; In tetrahydrofuran; at 25 ℃;
DOI:10.1016/j.bmcl.2013.03.031

Reference yield:

: 68716-51-8
2-(3,5-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 950482-85-6
5-(3,5-dichlorophenyl)-3-(5,6-dichloro-3-pyridyl)-5-trifluoromethyl-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium hydroxide / water; 1,2-dimethoxyethane; tetrahydrofuran / 75 °C

2: sodium hypochlorite / tetrahydrofuran / 25 °C

With sodium hypochlorite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2013.03.031