3-(6-aminomethyl-5-chloro-3-pyridyl)-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

Base Information

Chemical Name:3-(6-aminomethyl-5-chloro-3-pyridyl)-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole
CAS No.:950482-65-2
Molecular Formula:C₁₆H₁₁Cl₃F₃N₃O
Molecular Weight:424.637
Hs Code.:

Synonyms:3-(6-aminomethyl-5-chloro-3-pyridyl)-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

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Chemical Property of 3-(6-aminomethyl-5-chloro-3-pyridyl)-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

Chemical Property:

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Technology Process of 3-(6-aminomethyl-5-chloro-3-pyridyl)-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

There total 4 articles about 3-(6-aminomethyl-5-chloro-3-pyridyl)-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67492-50-6
(3,5-dichlorophenyl)boronic acid

: 950482-65-2
3-(6-aminomethyl-5-chloro-3-pyridyl)-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 3 h / Heating / reflux

2.1: N-chloro-succinimide / 1,2-dimethoxyethane / 4 h / 70 °C

2.2: 20 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl acetamide / 4.5 h / 80 - 120 °C

4.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / methanol; water / 2.5 h / 20 °C / 760.05 Torr

With hydrogenchloride; N-chloro-succinimide; hydrogen; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; N,N-dimethyl acetamide; water;

Reference yield:

: 950482-86-7
3-(5-chloro-6-cyano-3-pyridyl)-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

: 950482-65-2
3-(6-aminomethyl-5-chloro-3-pyridyl)-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

Guidance literature:: With hydrogenchloride; hydrogen; 5%-palladium/activated carbon; In methanol; water; at 20 ℃; for 2.5h; under 760.051 Torr;

Reference yield:

: 864725-22-4
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 950482-65-2
3-(6-aminomethyl-5-chloro-3-pyridyl)-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-chloro-succinimide / 1,2-dimethoxyethane / 4 h / 70 °C

1.2: 20 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl acetamide / 4.5 h / 80 - 120 °C

3.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / methanol; water / 2.5 h / 20 °C / 760.05 Torr

With hydrogenchloride; N-chloro-succinimide; hydrogen; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5%-palladium/activated carbon; In methanol; 1,2-dimethoxyethane; N,N-dimethyl acetamide; water;