2-(2-amino-5-(tert-butoxycarbonylamino)phenylamino)-4-chlorobenzoic acid

Base Information

Chemical Name:2-(2-amino-5-(tert-butoxycarbonylamino)phenylamino)-4-chlorobenzoic acid
CAS No.:1372589-70-2
Molecular Formula:C₁₈H₂₀ClN₃O₄
Molecular Weight:377.827
Hs Code.:

Synonyms:2-(2-amino-5-(tert-butoxycarbonylamino)phenylamino)-4-chlorobenzoic acid

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Chemical Property of 2-(2-amino-5-(tert-butoxycarbonylamino)phenylamino)-4-chlorobenzoic acid

Chemical Property:

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Technology Process of 2-(2-amino-5-(tert-butoxycarbonylamino)phenylamino)-4-chlorobenzoic acid

There total 7 articles about 2-(2-amino-5-(tert-butoxycarbonylamino)phenylamino)-4-chlorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372589-69-9
methyl 2-(2-amino-5-(tert-butoxycarbonylamino)phenylamino)-4-chlorobenzoate

: 1372589-70-2
2-(2-amino-5-(tert-butoxycarbonylamino)phenylamino)-4-chlorobenzoic acid

Guidance literature:: methyl 2-(2-amino-5-(tert-butoxycarbonylamino)phenylamino)-4-chlorobenzoate; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 60 ℃; for 16h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; at 20 ℃; pH=6;

Reference yield:

: 2-amino-4-(N-tert-butoxycarbonylamino)nitrobenzene

: 1372589-70-2
2-(2-amino-5-(tert-butoxycarbonylamino)phenylamino)-4-chlorobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / toluene / 16 h / 95 °C

2.1: hydrogen / Raney Ni / tetrahydrofuran; methanol / 3 h / 20 °C / 1551.49 Torr

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 16 h / 60 °C

3.2: 20 °C / pH 6

With water; hydrogen; caesium carbonate; lithium hydroxide; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; methanol; toluene; 1.1: Buchwald-Hartwig amination;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1372589-70-2
2-(2-amino-5-(tert-butoxycarbonylamino)phenylamino)-4-chlorobenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -10 °C

1.2: 18 h / -10 - 20 °C

2.1: caesium carbonate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / toluene / 16 h / 95 °C

3.1: hydrogen / Raney Ni / tetrahydrofuran; methanol / 3 h / 20 °C / 1551.49 Torr

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 16 h / 60 °C

4.2: 20 °C / pH 6

With water; hydrogen; potassium hexamethylsilazane; caesium carbonate; lithium hydroxide; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; methanol; toluene; 2.1: Buchwald-Hartwig amination;