(S)-dimethyl 2,2'-(ethyne-1,2-diyl)bis(3-((S)-2-((tert-butoxycarbonyl)amino)propanamido)benzoate)

Base Information

Chemical Name:(S)-dimethyl 2,2'-(ethyne-1,2-diyl)bis(3-((S)-2-((tert-butoxycarbonyl)amino)propanamido)benzoate)
CAS No.:1597416-60-8
Molecular Formula:C₃₄H₄₂N₄O₁₀
Molecular Weight:666.728
Hs Code.:

Synonyms:(S)-dimethyl 2,2'-(ethyne-1,2-diyl)bis(3-((S)-2-((tert-butoxycarbonyl)amino)propanamido)benzoate)

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Chemical Property of (S)-dimethyl 2,2'-(ethyne-1,2-diyl)bis(3-((S)-2-((tert-butoxycarbonyl)amino)propanamido)benzoate)

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Technology Process of (S)-dimethyl 2,2'-(ethyne-1,2-diyl)bis(3-((S)-2-((tert-butoxycarbonyl)amino)propanamido)benzoate)

There total 5 articles about (S)-dimethyl 2,2'-(ethyne-1,2-diyl)bis(3-((S)-2-((tert-butoxycarbonyl)amino)propanamido)benzoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1597416-57-3
(S)-methyl 3-(2-((tert-butoxycarbonyl)amino)propanamido)-2-iodobenzoate

: 1597416-59-5
(S)-methyl 3-(2-((tert-butoxycarbonyl)amino)propanamido)-2-ethynylbenzoate

: 1597416-60-8
(S)-dimethyl 2,2'-(ethyne-1,2-diyl)bis(3-((S)-2-((tert-butoxycarbonyl)amino)propanamido)benzoate)

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 16h; Inert atmosphere;
DOI:10.1002/anie.201309353

Reference yield:

: 283173-76-2
methyl 3-amino-2-iodobenzoate

: 1597416-60-8
(S)-dimethyl 2,2'-(ethyne-1,2-diyl)bis(3-((S)-2-((tert-butoxycarbonyl)amino)propanamido)benzoate)

Guidance literature:: Multi-step reaction with 2 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; dicyclohexyl-carbodiimide / tetrahydrofuran / 16.25 h / -10 - 60 °C / Inert atmosphere

2: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 60 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling;
DOI:10.1002/anie.201309353

Reference yield:

: 93415-79-3
methyl 2-iodo-3-nitrobenzoate

: 1597416-60-8
(S)-dimethyl 2,2'-(ethyne-1,2-diyl)bis(3-((S)-2-((tert-butoxycarbonyl)amino)propanamido)benzoate)

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; iron(III) chloride / 2.5 h / 110 °C / Reflux; Inert atmosphere

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; dicyclohexyl-carbodiimide / tetrahydrofuran / 16.25 h / -10 - 60 °C / Inert atmosphere

3: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 60 °C / Inert atmosphere

With iron(III) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide; 3: |Sonogashira Cross-Coupling;
DOI:10.1002/anie.201309353