4-(7-((tert-butyldimethylsilyl)oxy)quinoxalin-2-yl)-N,N-dimethylaniline

Base Information

• Chemical Name: 4-(7-((tert-butyldimethylsilyl)oxy)quinoxalin-2-yl)-N,N-dimethylaniline
• CAS No.: 1437281-15-6
• Molecular Formula: C₂₂H₂₉N₃OSi
• Molecular Weight: 379.577
• Mol file: 1437281-15-6.mol

Synonyms:4-(7-((tert-butyldimethylsilyl)oxy)quinoxalin-2-yl)-N,N-dimethylaniline

Chemical Property of 4-(7-((tert-butyldimethylsilyl)oxy)quinoxalin-2-yl)-N,N-dimethylaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(7-((tert-butyldimethylsilyl)oxy)quinoxalin-2-yl)-N,N-dimethylaniline

There total 6 articles about 4-(7-((tert-butyldimethylsilyl)oxy)quinoxalin-2-yl)-N,N-dimethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.3%

4-((tert-butyldimethylsilyl)oxy)benzene-1,2-diamine (1416374-31-6) + 2-bromo-1-(4-(dimethylamino)phenyl)ethanone (37904-72-6) → 4-(7-((tert-butyldimethylsilyl)oxy)quinoxalin-2-yl)-N,N-dimethylaniline (1437281-15-6)

Guidance literature:

In dimethyl sulfoxide; at 20 ℃; for 4h;

DOI:10.1021/ml4000707

Reference yield:

2,2-dibromo-1-(4-(dimethylamino)phenyl)ethan-1-one (210832-81-8) → 4-(7-((tert-butyldimethylsilyl)oxy)quinoxalin-2-yl)-N,N-dimethylaniline (1437281-15-6)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphonic acid diethyl ester; triethylamine / tetrahydrofuran / 11 h / 0 - 20 °C

2: dimethyl sulfoxide / 4 h / 20 °C

With triethylamine; phosphonic acid diethyl ester; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1021/ml4000707

Reference yield:

4-{[tert-butyl(dimethyl)silyl]oxy}-2-nitroaniline (215656-99-8) → 4-(7-((tert-butyldimethylsilyl)oxy)quinoxalin-2-yl)-N,N-dimethylaniline (1437281-15-6)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / methanol; dichloromethane / 7 h / 20 °C

2: dimethyl sulfoxide / 4 h / 20 °C

With palladium on activated charcoal; hydrogen; In methanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1021/ml4000707

upstream raw materials:

2,2-dibromo-1-(4-(dimethylamino)phenyl)ethan-1-one

4-((tert-butyldimethylsilyl)oxy)benzene-1,2-diamine

2-bromo-1-(4-(dimethylamino)phenyl)ethanone

4-{[tert-butyl(dimethyl)silyl]oxy}-2-nitroaniline

Downstream raw materials:

2-((3-(4-(dimethylamino)phenyl)quinoxalin-6-yl)oxy)ethanol

2-((3-(4-(dimethylamino)phenyl)quinoxalin-6-yl)oxy)ethyl 4-methylbenzenesulfonate

tert-butyl (4-(7-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)phenyl)(methyl)carbamate

tert-butyl (4-(7-(2-hydroxyethoxy)quinoxalin-2-yl)phenyl)(methyl)carbamate