tert-butyl 4-((5-((phenoxycarbonyl)amino)-1-phenyl-1H-pyrazol-3-yl)methoxy)piperidine-1-carboxylate

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Chemical Name:tert-butyl 4-((5-((phenoxycarbonyl)amino)-1-phenyl-1H-pyrazol-3-yl)methoxy)piperidine-1-carboxylate
CAS No.:1414572-54-5
Molecular Formula:C₂₇H₃₂N₄O₅
Molecular Weight:492.575
Hs Code.:

Synonyms:tert-butyl 4-((5-((phenoxycarbonyl)amino)-1-phenyl-1H-pyrazol-3-yl)methoxy)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-((5-((phenoxycarbonyl)amino)-1-phenyl-1H-pyrazol-3-yl)methoxy)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-((5-((phenoxycarbonyl)amino)-1-phenyl-1H-pyrazol-3-yl)methoxy)piperidine-1-carboxylate

There total 5 articles about tert-butyl 4-((5-((phenoxycarbonyl)amino)-1-phenyl-1H-pyrazol-3-yl)methoxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1414571-23-5
tert-butyl 4-((5-amino-1-phenyl-1H-pyrazol-3-yl)methoxy)piperidine-1-carboxylate

: 1885-14-9
phenyl chloroformate

: 1414572-54-5
tert-butyl 4-((5-((phenoxycarbonyl)amino)-1-phenyl-1H-pyrazol-3-yl)methoxy)piperidine-1-carboxylate

Guidance literature:: With sodium hydroxide; In ethyl acetate; at 20 ℃; for 3h; Cooling with ice;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1414572-54-5
tert-butyl 4-((5-((phenoxycarbonyl)amino)-1-phenyl-1H-pyrazol-3-yl)methoxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.25 h / -78 °C

2.2: 1 h / -78 °C

3.1: ethanol / 60 h / 60 °C

4.1: sodium hydroxide / ethyl acetate / 3 h / 20 °C / Cooling with ice

With n-butyllithium; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; ethanol; ethyl acetate;

Reference yield:

: 189889-45-0
4-(ethoxycarbonylmethoxy)piperidine-1-carboxylic acid tert-butylester

: 1414572-54-5
tert-butyl 4-((5-((phenoxycarbonyl)amino)-1-phenyl-1H-pyrazol-3-yl)methoxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.25 h / -78 °C

1.2: 1 h / -78 °C

2.1: ethanol / 60 h / 60 °C

3.1: sodium hydroxide / ethyl acetate / 3 h / 20 °C / Cooling with ice

With n-butyllithium; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; ethanol; ethyl acetate;