ethyl 3-{6-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]pyridin-3-yl}propanoate

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Chemical Name:ethyl 3-{6-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]pyridin-3-yl}propanoate
CAS No.:1356602-12-4
Molecular Formula:C₂₆H₂₈N₂O₅
Molecular Weight:448.519
Hs Code.:

Synonyms:ethyl 3-{6-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]pyridin-3-yl}propanoate

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Chemical Property of ethyl 3-{6-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]pyridin-3-yl}propanoate

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Technology Process of ethyl 3-{6-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]pyridin-3-yl}propanoate

There total 9 articles about ethyl 3-{6-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]pyridin-3-yl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1356602-09-9
ethyl 3-(6-{[4-(2-oxo-2-phenylethoxy)benzyl]oxy}pyridin-3-yl)propanoate

: 593-56-6
N-methoxylamine hydrochloride

: 1356602-12-4
ethyl 3-{6-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]pyridin-3-yl}propanoate

Guidance literature:: With pyridine; In ethanol; at 80 ℃; for 3h;

Reference yield:

: 623-05-2
(4-hydroxyphenyl)methanol

: 1356602-12-4
ethyl 3-{6-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]pyridin-3-yl}propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetonitrile / 2 h / 20 - 80 °C

2.1: phosphorus tribromide / dichloromethane / 1.08 h / 0 - 20 °C

2.2: 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 12 h / 20 - 80 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

4.2: 12 h / 0 - 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 20 °C

6.1: pyridine / ethanol / 3 h / 80 °C

With pyridine; hydrogen; phosphorus tribromide; sodium hydride; potassium carbonate; caesium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 70-11-1
α-bromoacetophenone

: 1356602-12-4
ethyl 3-{6-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]pyridin-3-yl}propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetonitrile / 2 h / 20 - 80 °C

2.1: phosphorus tribromide / dichloromethane / 1.08 h / 0 - 20 °C

2.2: 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 12 h / 20 - 80 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

4.2: 12 h / 0 - 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 20 °C

6.1: pyridine / ethanol / 3 h / 80 °C

With pyridine; hydrogen; phosphorus tribromide; sodium hydride; potassium carbonate; caesium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;