(E)-3-(4-hydroxy-3-methoxyphenyl)-1-[4-(3,4,5-trimethoxybenzoyl)piperazino]-2-propen-1-one

Base Information

• Chemical Name: (E)-3-(4-hydroxy-3-methoxyphenyl)-1-[4-(3,4,5-trimethoxybenzoyl)piperazino]-2-propen-1-one
• CAS No.: 1226909-06-3
• Molecular Formula: C₂₄H₂₈N₂O₇
• Molecular Weight: 456.496

Synonyms:(E)-3-(4-hydroxy-3-methoxyphenyl)-1-[4-(3,4,5-trimethoxybenzoyl)piperazino]-2-propen-1-one

Chemical Property of (E)-3-(4-hydroxy-3-methoxyphenyl)-1-[4-(3,4,5-trimethoxybenzoyl)piperazino]-2-propen-1-one

Chemical Property:

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Technology Process of (E)-3-(4-hydroxy-3-methoxyphenyl)-1-[4-(3,4,5-trimethoxybenzoyl)piperazino]-2-propen-1-one

There total 1 articles about (E)-3-(4-hydroxy-3-methoxyphenyl)-1-[4-(3,4,5-trimethoxybenzoyl)piperazino]-2-propen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

trans-4-hydroxy-3-methoxycinnamic acid chloride (138769-50-3,108608-04-4) + piperazin-1-yl-(3,4,5,trimethoxy-phenyl)-methanone (964-65-8) → (E)-3-(4-hydroxy-3-methoxyphenyl)-1-[4-(3,4,5-trimethoxybenzoyl)piperazino]-2-propen-1-one (1226909-06-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2010.05.041

Reference yield: 75.0%

(E)-3-(4-hydroxy-3-methoxyphenyl)-1-[4-(3,4,5-trimethoxybenzoyl)piperazino]-2-propen-1-one (1226909-06-3) + (2S)-N-[4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal (343308-55-4) → (2S)-N-{4-[3-[2-methoxy-4-((E)-3-oxo-3-[4-(3,4,5-trimethoxybenzoyl)piperazino]-1-propenyl)phenoxy]propoxy]-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl dithioacetal (1226908-98-0)

Guidance literature:

With potassium carbonate; In acetonitrile; for 12h; Reflux;

DOI:10.1016/j.ejmech.2010.05.041

Reference yield: 74.0%

4-[(6-bromohexyl)oxy]-5-methoxy-2-nitrophenyl2-[di(ethylsulfanyl)methyl]tetrahydro-1H-1-pyrrolylmethanone (1080662-00-5) + (E)-3-(4-hydroxy-3-methoxyphenyl)-1-[4-(3,4,5-trimethoxybenzoyl)piperazino]-2-propen-1-one (1226909-06-3) → (2S)-N-{4-[6-[2-methoxy-4-((E)-3-oxo-3-[4-(3,4,5-trimethoxybenzoyl)piperazino]-1-propenyl)phenoxy]hexyloxy]-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl dithioacetal (1246890-26-5)

Guidance literature:

With potassium carbonate; In acetonitrile; for 12h; Reflux;

DOI:10.1016/j.ejmech.2010.05.041

upstream raw materials:

trans-4-hydroxy-3-methoxycinnamic acid chloride

piperazin-1-yl-(3,4,5,trimethoxy-phenyl)-methanone

Downstream raw materials:

(2S)-N-{4-[3-[2-methoxy-4-((E)-3-oxo-3-[4-(3,4,5-trimethoxybenzoyl)piperazino]-1-propenyl)phenoxy]propoxy]-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl dithioacetal

(2S)-N-{4-[6-[2-methoxy-4-((E)-3-oxo-3-[4-(3,4,5-trimethoxybenzoyl)piperazino]-1-propenyl)phenoxy]hexyloxy]-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl dithioacetal

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