2'-O-{2-[3-(7,8-didehydro-1,2:5,6-dibenzocyclooctynyl)oxyamido]ethyl}-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine 3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Base Information

Chemical Name:2'-O-{2-[3-(7,8-didehydro-1,2:5,6-dibenzocyclooctynyl)oxyamido]ethyl}-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine 3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
CAS No.:1412707-66-4
Molecular Formula:C₅₉H₆₄N₅O₁₁P
Molecular Weight:1050.16
Hs Code.:

2'-O-{2-[3-(7,8-didehydro-1,2:5,6-dibenzocyclooctynyl)oxyamido]ethyl}-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine 3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Synonyms:2'-O-{2-[3-(7,8-didehydro-1,2:5,6-dibenzocyclooctynyl)oxyamido]ethyl}-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine 3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

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Chemical Property of 2'-O-{2-[3-(7,8-didehydro-1,2:5,6-dibenzocyclooctynyl)oxyamido]ethyl}-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine 3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

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Technology Process of 2'-O-{2-[3-(7,8-didehydro-1,2:5,6-dibenzocyclooctynyl)oxyamido]ethyl}-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine 3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

There total 7 articles about 2'-O-{2-[3-(7,8-didehydro-1,2:5,6-dibenzocyclooctynyl)oxyamido]ethyl}-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine 3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.4%

: 1412707-61-9
2'-O-{2-[3-(7,8-didehydro-1,2:5,6-dibenzocyclooctynyl)oxyamido]ethyl}-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1412707-66-4
2'-O-{2-[3-(7,8-didehydro-1,2:5,6-dibenzocyclooctynyl)oxyamido]ethyl}-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine 3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 22423-26-3
O-2,2'-cyclo-5-methyluridine

: 1412707-66-4
2'-O-{2-[3-(7,8-didehydro-1,2:5,6-dibenzocyclooctynyl)oxyamido]ethyl}-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine 3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / 20 °C

2: sodium hydrogencarbonate; titanium(IV) isopropylate / tetrahydrofuran / 150 °C

3: triethylamine / dichloromethane

4: sodium azide; 18-crown-6 ether / N,N-dimethyl-formamide

5: triphenylphosphine; water / tetrahydrofuran

6: triethylamine / dichloromethane / 5.25 h / 20 °C / Inert atmosphere

7: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

With pyridine; titanium(IV) isopropylate; sodium azide; 18-crown-6 ether; water; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1263796-39-9
C₃₃H₃₅N₅O₈

: 1412707-66-4
2'-O-{2-[3-(7,8-didehydro-1,2:5,6-dibenzocyclooctynyl)oxyamido]ethyl}-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine 3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; water / tetrahydrofuran

2: triethylamine / dichloromethane / 5.25 h / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

With water; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane;