2'-O-{2-[3-(7,8-didehydro-1,2:5,6-dibenzocyclooctynyl)oxyamido]ethyl}-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine

Base Information

Chemical Name:2'-O-{2-[3-(7,8-didehydro-1,2:5,6-dibenzocyclooctynyl)oxyamido]ethyl}-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine
CAS No.:1412707-61-9
Molecular Formula:C₅₀H₄₇N₃O₁₀
Molecular Weight:849.937
Hs Code.:

Synonyms:2'-O-{2-[3-(7,8-didehydro-1,2:5,6-dibenzocyclooctynyl)oxyamido]ethyl}-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine

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Chemical Property of 2'-O-{2-[3-(7,8-didehydro-1,2:5,6-dibenzocyclooctynyl)oxyamido]ethyl}-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine

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Technology Process of 2'-O-{2-[3-(7,8-didehydro-1,2:5,6-dibenzocyclooctynyl)oxyamido]ethyl}-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine

There total 6 articles about 2'-O-{2-[3-(7,8-didehydro-1,2:5,6-dibenzocyclooctynyl)oxyamido]ethyl}-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1027338-09-5
11,12-didehydro-5,6-dihydrodibenzo[a,e]cycloocten-5-yl carbonic acid 4-nitrophenyl ester

: 242147-79-1
2'-O-[2-(amino)ethyl]-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine

: 1412707-61-9
2'-O-{2-[3-(7,8-didehydro-1,2:5,6-dibenzocyclooctynyl)oxyamido]ethyl}-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 5.25h; Inert atmosphere;

Reference yield:

: 22423-26-3
O-2,2'-cyclo-5-methyluridine

: 1412707-61-9
2'-O-{2-[3-(7,8-didehydro-1,2:5,6-dibenzocyclooctynyl)oxyamido]ethyl}-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / 20 °C

2: sodium hydrogencarbonate; titanium(IV) isopropylate / tetrahydrofuran / 150 °C

3: triethylamine / dichloromethane

4: sodium azide; 18-crown-6 ether / N,N-dimethyl-formamide

5: triphenylphosphine; water / tetrahydrofuran

6: triethylamine / dichloromethane / 5.25 h / 20 °C / Inert atmosphere

With pyridine; titanium(IV) isopropylate; sodium azide; 18-crown-6 ether; water; sodium hydrogencarbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 817623-11-3
2,2'-anhydro-1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl-5-methyluridine]

: 1412707-61-9
2'-O-{2-[3-(7,8-didehydro-1,2:5,6-dibenzocyclooctynyl)oxyamido]ethyl}-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate; titanium(IV) isopropylate / tetrahydrofuran / 150 °C

2: triethylamine / dichloromethane

3: sodium azide; 18-crown-6 ether / N,N-dimethyl-formamide

4: triphenylphosphine; water / tetrahydrofuran

5: triethylamine / dichloromethane / 5.25 h / 20 °C / Inert atmosphere

With titanium(IV) isopropylate; sodium azide; 18-crown-6 ether; water; sodium hydrogencarbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;