5-[(2-hydroxy-6oxo-1-cyolohexen-1-yl)carbonyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetaldehyde 1-(O-methyloxime)

Base Information

Chemical Name:5-[(2-hydroxy-6oxo-1-cyolohexen-1-yl)carbonyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetaldehyde 1-(O-methyloxime)
CAS No.:1395046-66-8
Molecular Formula:C₂₀H₁₉N₃O₅
Molecular Weight:381.388
Hs Code.:

Synonyms:5-[(2-hydroxy-6oxo-1-cyolohexen-1-yl)carbonyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetaldehyde 1-(O-methyloxime)

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Chemical Property of 5-[(2-hydroxy-6oxo-1-cyolohexen-1-yl)carbonyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetaldehyde 1-(O-methyloxime)

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Technology Process of 5-[(2-hydroxy-6oxo-1-cyolohexen-1-yl)carbonyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetaldehyde 1-(O-methyloxime)

There total 6 articles about 5-[(2-hydroxy-6oxo-1-cyolohexen-1-yl)carbonyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetaldehyde 1-(O-methyloxime) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1395047-03-6
3-oxo-1-cyclohexen-1-yl 1,6-dihydro-1-[2-(methoxyimino)ethyl]6-oxo-2-phenyl-5-pyrimidinecarboxylate

: 1395046-66-8
5-[(2-hydroxy-6oxo-1-cyolohexen-1-yl)carbonyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetaldehyde 1-(O-methyloxime)

Guidance literature:: With triethylamine; 2-hydroxy-2-methylpropanenitrile; In acetonitrile; at 20 ℃; for 6h;

Reference yield:

: 308276-58-6
methyl 1-(2,2-dimethoxyethyl)-1,6-dihydro-6-oxo-2-phenyl-5-pyrimidinecarboxylate

: 1395046-66-8
5-[(2-hydroxy-6oxo-1-cyolohexen-1-yl)carbonyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetaldehyde 1-(O-methyloxime)

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / ethanol / 4 h / Reflux

2.1: lithium iodide / ethyl acetate / 4 h / Reflux

2.2: pH 4

3.1: 1-methyl pyridinium iodide / dichloromethane / 0.25 h / 20 °C

3.2: 12 h / 20 °C

4.1: triethylamine / 2-hydroxy-2-methylpropanenitrile / acetonitrile / 6 h / 20 °C

With 1-methyl pyridinium iodide; triethylamine; lithium iodide; toluene-4-sulfonic acid; 2-hydroxy-2-methylpropanenitrile; In ethanol; dichloromethane; ethyl acetate; acetonitrile;

Reference yield:

: 100-47-0
benzonitrile

: 1395046-66-8
5-[(2-hydroxy-6oxo-1-cyolohexen-1-yl)carbonyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetaldehyde 1-(O-methyloxime)

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium methylate / methanol / 12 h / 20 °C / Inert atmosphere

1.2: 0.33 h

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 6 h / 120 °C

3.1: toluene-4-sulfonic acid / ethanol / 4 h / Reflux

4.1: lithium iodide / ethyl acetate / 4 h / Reflux

4.2: pH 4

5.1: 1-methyl pyridinium iodide / dichloromethane / 0.25 h / 20 °C

5.2: 12 h / 20 °C

6.1: triethylamine / 2-hydroxy-2-methylpropanenitrile / acetonitrile / 6 h / 20 °C

With sodium methylate; 1-methyl pyridinium iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium iodide; toluene-4-sulfonic acid; 2-hydroxy-2-methylpropanenitrile; In methanol; ethanol; dichloromethane; ethyl acetate; acetonitrile;