Technology Process of ethyl 4-[5-fluoro-2-(methyloxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]butanoate
There total 5 articles about ethyl 4-[5-fluoro-2-(methyloxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]butanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: caesium carbonate; tri-tert-butyl phosphine / tris-(dibenzylideneacetone)dipalladium(0) / tetrahydrofuran / 20 °C / Inert atmosphere
2.1: ammonium chloride; iron / 90 °C
3.1: sodium nitrite; hydrogen bromide / acetonitrile; water / 0.17 h / 0 °C
3.2: 1 h / 50 °C
4.1: tricyclohexylphosphine; potassium acetate / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 0.75 h / 150 °C / Inert atmosphere; Sealed; Microwave irradiation
With
tri-tert-butyl phosphine; hydrogen bromide; potassium acetate; iron; ammonium chloride; caesium carbonate; sodium nitrite; tricyclohexylphosphine;
tris-(dibenzylideneacetone)dipalladium(0);
In
tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
With
potassium acetate;
tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine;
In
N,N-dimethyl-formamide;
at 150 ℃;
for 0.75h;
Inert atmosphere;
Sealed;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: nitric acid; sulfuric acid / 0.5 h / -10 °C
2.1: caesium carbonate; tri-tert-butyl phosphine / tris-(dibenzylideneacetone)dipalladium(0) / tetrahydrofuran / 20 °C / Inert atmosphere
3.1: ammonium chloride; iron / 90 °C
4.1: sodium nitrite; hydrogen bromide / acetonitrile; water / 0.17 h / 0 °C
4.2: 1 h / 50 °C
5.1: tricyclohexylphosphine; potassium acetate / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 0.75 h / 150 °C / Inert atmosphere; Sealed; Microwave irradiation
With
tri-tert-butyl phosphine; sulfuric acid; hydrogen bromide; nitric acid; potassium acetate; iron; ammonium chloride; caesium carbonate; sodium nitrite; tricyclohexylphosphine;
tris-(dibenzylideneacetone)dipalladium(0);
In
tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
