81638-86-0

Upstream product

• 69193-13-1 Cbz-L-Phe-L-Leu-NH₂ 
• 687-51-4 H-L-Leu-NH₂ 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 1161-13-3 N-Cbz-L-Phe 
• 10466-61-2 (2S)-amino-4-methylpentanamide hydrochloride 
• 81638-94-0 O-(t-butyloxycarbonyl-L-phenylalanyl)-2-pyridylmethylketoxime 
• 74257-73-1 tert-butyl ((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate 

Downstream Products

• 133851-92-0 Pht-GlyΨ(CH2O)Gly-Phe-Leu-NH2 
• 75286-46-3 amide of N-t-butyloxycarbonylglycylglycyl-L-phenylalanyl-L-leucine 
• 81638-88-2 amide of N-t-butyloxycarbonyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine 
• 82948-92-3 [des-tyr¹]-leucine enkephalinamide 
• 1313481-74-1 Boc-Tyr(tBu)-Gly-Gly-Phe-Leu-NH₂ 
• 93200-07-8 Boc-Gly-Phe-Leu-NH₂ 
• 133851-94-2 AcOH*H-GlyΨ(CH2O)Gly-Phe-Leu-NH2 
• 81638-90-6 amide of N-t-butyloxycarbonyl-β-alanyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine 
• 81638-87-1 hydrochloride of amide of glycylglycyl-L-phenylalanyl-L-leucine 
• 79396-86-4 Boc-L-Tyr-Gly-Gly-L-Phe-L-Leu-NH₂ 

Relevant academic research and scientific papers

Environmentally Conscious In-Water Peptide Synthesis Using Boc Strategy

Seeking a more environmentally balanced method of peptide synthesis, we are focusing on developing organic solvent-free synthetic methods using water, an environmentally friendly solvent. In current peptide synthesis, the most common building blocks are Boc- and Fmoc-protected amino acids, which are highly soluble in organic solvents. We previously reported a technique for solid-phase peptide synthesis in water that utilizes Fmoc-amino acids converted to water-dispersible nanoparticles. The Boc strategy is well-known to be suitable for the industrial chemistry and green chemistry, because only gases are generated without any other by-products in the deprotection step of Boc group. Here we summarize in-water both liquid and solid-phase method using Boc-amino acids based on MW-assisted coupling reaction of nanosized reactants, nanoparticles and nanomicelles.

COMPOSITIONS AND METHODS FOR INHIBITING PROTEIN EMBRYONIC ECTODERM DEVELOPMENT ACTIVITY AND TREATING DISEASE

The invention provides compounds that are inhibitors of the protein embryonic ectoderm development (EED), pharmaceutical compositions, their use in modulating the activity of EED, and their use in the treatment of medical disorders, such as cancer. The invention further provides methods of treating medical disorders, such as cancer, and covalently modifying and/or modulating the activity of EED, using an agent that reacts with, and forms a covalent bond to, cysteine324 of EED.

Peptide synthesis 'in water' by a solution-phase method using water-dispersible nanoparticle Boc-amino acid

Regulatory pressure has compelled the chemical manufacturing industry to reduce the use of organic solvents in synthetic chemistry, and there is currently a strong focus on replacing these solvents with water. Here, we describe an efficient in-water solution-phase peptide synthesis method using Boc-amino acids. It is based on a coupling reaction utilizing suspended water-dispersible nanoparticle reactants. Using this method, peptides were obtained in good yield and with high purity.

O-(N-ACYLAMINOACYL)-2-PYRIDYLMETHYLKETOXIMES AND THEIR USE IN PEPTIDE SYNTHESIS

Preparation of Leu-enkephalin, Met-enkephalin and one analog of Leu-enkephalin by using O-(N-acylaminoacyl)-2-pyridylketoximes is described.Both the side products and the unreacted active amino acid derivatives were removed by utilizing the formation of a copper complex with 2-pyridylmethylketoxime.